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Literature DB >> 6355195

Detection of antibodies against Legionella pneumophila serogroups 1 to 6 and the Leiden-1 strain by micro ELISA and immunofluorescence assay.

P Herbrink, P L Meenhorst, D G Groothuis, H V Munckhof, R Bax, C J Meijer, J Lindeman.

Abstract

One hundred and seventy-five human sera were tested for the presence of type-specific antibodies against L pneumophila serogroups 1 to 6 and the Leiden-1 strain by means of an enzyme linked immunosorbent assay (ELISA) and compared with the results obtained by the indirect immunofluorescence assay (IFA). A high correlation (correlation coefficient 0.92) between both methods was found. No consistent pattern of IgG, IgA and IgM classes of antibody titres against L pneumophila were found. In the sera of 15 of 17 patients with a proven L pneumophila pneumonia, IgM class antibodies against L pneumophila could be detected. A "polyvalent" ELISA was developed which permits rapid routine screening of human sera for antibodies against L pneumophila serogroups 1 to 6 and the Leiden-1 strain.

Entities: Disease Species

Mesh：

Substances：

Year: 1983 PMID： 6355195 PMCID： PMC498540 DOI： 10.1136/jcp.36.11.1246

Source DB: PubMed Journal: J Clin Pathol ISSN： 0021-9746 Impact factor: 3.411

14 in total

1. Serology of Legionnaires disease: comparison of indirect fluorescent antibody, immune adherence hemagglutination, and indirect hemagglutination tests.

Authors: D A Lennette; E T Lennette; B B Wentworth; M L French; G L Lattimer
Journal: J Clin Microbiol Date: 1979-12 Impact factor: 5.948

2. Measure of immunoglobulin G-, M-, and A-specific titers against Legionella pneumophila and inhibition of titers against nonspecific, gram-negative bacterial antigens in the indirect immunofluorescence test for legionellosis.

Authors: H W Wilkinson; C E Farshy; B J Fikes; D D Cruce; L P Yealy
Journal: J Clin Microbiol Date: 1979-11 Impact factor: 5.948

3. Impaired humoral immunity in treated Hodgkin's disease.

Authors: S A Weitzman; A C Aisenberg; G R Siber; D H Smith
Journal: N Engl J Med Date: 1977-08-04 Impact factor: 91.245

4. Four serogroups of Legionnaires' disease bacteria defined by direct immunofluorescence.

Authors: R M McKinney; L Thacker; P P Harris; K R Lewallen; G A Hebert; P H Edelstein; B M Thomason
Journal: Ann Intern Med Date: 1979-04 Impact factor: 25.391

5. A fifth serogroup of Legionella pneumophila.

Authors: A C England; R M McKinney; P Skaliy; G W Gorman
Journal: Ann Intern Med Date: 1980-07 Impact factor: 25.391

6. The antibody response in Legionnaires' disease.

Authors: J Nagington; T G Wreghitt; J O Tobin; A D Macrae
Journal: J Hyg (Lond) Date: 1979-10

7. Detection of antibodies to legionnaires disease organism by microagglutination and micro-enzyme-linked immunosorbent assay tests.

Authors: C E Farshy; G C Klein; J C Feeley
Journal: J Clin Microbiol Date: 1978-04 Impact factor: 5.948

8. Indirect immunofluorescence test for serodiagnosis of Legionnaires disease: evidence for serogroup diversity of Legionnaires disease bacterial antigens and for multiple specificity of human antibodies.

Authors: H W Wilkinson; B J Fikes; D D Cruce
Journal: J Clin Microbiol Date: 1979-03 Impact factor: 5.948

Detection of antibodies against Legionella pneumophila serogroups 1 to 6 and the Leiden-1 strain by micro ELISA and immunofluorescence assay.

1. Serology of Legionnaires disease: comparison of indirect fluorescent antibody, immune adherence hemagglutination, and indirect hemagglutination tests.

2. Measure of immunoglobulin G-, M-, and A-specific titers against Legionella pneumophila and inhibition of titers against nonspecific, gram-negative bacterial antigens in the indirect immunofluorescence test for legionellosis.

3. Impaired humoral immunity in treated Hodgkin's disease.

4. Four serogroups of Legionnaires' disease bacteria defined by direct immunofluorescence.

5. A fifth serogroup of Legionella pneumophila.

6. The antibody response in Legionnaires' disease.

7. Detection of antibodies to legionnaires disease organism by microagglutination and micro-enzyme-linked immunosorbent assay tests.

8. Indirect immunofluorescence test for serodiagnosis of Legionnaires disease: evidence for serogroup diversity of Legionnaires disease bacterial antigens and for multiple specificity of human antibodies.

9. "Upper limits of normal" antistreptolysin O and antideoxyribonuclease B titers.

10. Pittsburgh pneumonia agent: direct isolation from human lung tissue.

Review 1. Diagnosis of Legionella infection in Legionnaires' disease.

Review 2. Laboratory diagnosis of infections caused by legionellae.