Literature DB >> 6354189

Mechanism of action of the antibiotic thiolactomycin inhibition of fatty acid synthesis of Escherichia coli.

T Hayashi, O Yamamoto, H Sasaki, A Kawaguchi, H Okazaki.   

Abstract

Thiolactomycin, an antibiotic with the structure of (4S)-(2E,5E)-2,4,6-trimethyl-3-hydroxy-2,5,7-octatriene-4-thiolide, inhibits the incorporation of [14C]acetate into cellular fatty acids of Escherichia coli. This antibiotic inhibits the fatty acid synthetase system of E. coli. However, the fatty acid synthetases from Saccharomyces cerevisiae, Candida albicans and rat liver are insensitive to thiolactomycin. This effect may account for the antibacterial activity of thiolactomycin and for its low toxicity in animals.

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Year:  1983        PMID： 6354189     DOI： 10.1016/s0006-291x(83)80050-3

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  30 in total

1.  Structure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli.

Authors:  Pilho Kim; Yong-Mei Zhang; Gautham Shenoy; Quynh-Anh Nguyen; Helena I Boshoff; Ujjini H Manjunatha; Michael B Goodwin; John Lonsdale; Allen C Price; Darcie J Miller; Ken Duncan; Stephen W White; Charles O Rock; Clifton E Barry; Cynthia S Dowd
Journal:  J Med Chem       Date:  2006-01-12       Impact factor: 7.446

2.  Overproduction of beta-ketoacyl-acyl carrier protein synthase I imparts thiolactomycin resistance to Escherichia coli K-12.

Authors:  J T Tsay; C O Rock; S Jackowski
Journal:  J Bacteriol       Date:  1992-01       Impact factor: 3.490

3.  Fatty acid biosynthesis in Pseudomonas aeruginosa: cloning and characterization of the fabAB operon encoding beta-hydroxyacyl-acyl carrier protein dehydratase (FabA) and beta-ketoacyl-acyl carrier protein synthase I (FabB).

Authors:  T T Hoang; H P Schweizer
Journal:  J Bacteriol       Date:  1997-09       Impact factor: 3.490

4.  In vivo and in vitro effects of thiolactomycin on fatty acid biosynthesis in Streptomyces collinus.

Authors:  K K Wallace; S Lobo; L Han; H A McArthur; K A Reynolds
Journal:  J Bacteriol       Date:  1997-06       Impact factor: 3.490

5.  FabH mutations confer resistance to FabF-directed antibiotics in Staphylococcus aureus.

Authors:  Joshua B Parsons; Jiangwei Yao; Matthew W Frank; Charles O Rock
Journal:  Antimicrob Agents Chemother       Date:  2014-11-17       Impact factor: 5.191

6.  Structure of the human beta-ketoacyl [ACP] synthase from the mitochondrial type II fatty acid synthase.

Authors:  Caspar Elo Christensen; Birthe B Kragelund; Penny von Wettstein-Knowles; Anette Henriksen
Journal:  Protein Sci       Date:  2007-02       Impact factor: 6.725

Review 7.  Bacterial fatty acid metabolism in modern antibiotic discovery.

Authors:  Jiangwei Yao; Charles O Rock
Journal:  Biochim Biophys Acta Mol Cell Biol Lipids       Date:  2016-09-23       Impact factor: 4.698

8.  Characterization of beta-ketoacyl-acyl carrier protein synthase III from Streptomyces glaucescens and its role in initiation of fatty acid biosynthesis.

Authors:  L Han; S Lobo; K A Reynolds
Journal:  J Bacteriol       Date:  1998-09       Impact factor: 3.490

9.  Slow onset inhibition of bacterial beta-ketoacyl-acyl carrier protein synthases by thiolactomycin.

Authors:  Carl A Machutta; Gopal R Bommineni; Sylvia R Luckner; Kanishk Kapilashrami; Bela Ruzsicska; Carlos Simmerling; Caroline Kisker; Peter J Tonge
Journal:  J Biol Chem       Date:  2009-12-16       Impact factor: 5.157

Review 10.  'FAS't inhibition of malaria.

Authors:  Avadhesha Surolia; T N C Ramya; V Ramya; Namita Surolia
Journal:  Biochem J       Date:  2004-11-01       Impact factor: 3.857
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