| Literature DB >> 6353530 |
P F Wright, J D Cherry, H M Foy, W P Glezen, C B Hall, K McIntosh, A S Monto, R H Parrott, B Portnoy, L H Taber.
Abstract
Clinical trials of monovalent A/USSR/77 (H1N1) and trivalent A/USSR/77 (H1N1), A/Texas/77 (H3N2), and B/Hong Kong/72 inactivated influenza virus vaccines were carried out in 358 children and adolescents. Only split-virus vaccines were administered to children younger than 13 years of age. No serious local or systemic reactions were observed among the study participants. Two doses of vaccine containing 7-20 micrograms of the A/USSR/77 (H1N1) viral antigen were required to achieve serum titers of hemagglutinin-inhibiting (HA1) antibody greater than 1:40. However, single doses containing 7-20 micrograms of the A/Texas/77 (H3N2) or B/Hong Kong/72 antigens stimulated serum HAI antibody levels of 1:40.Entities:
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Year: 1983 PMID： 6353530 DOI： 10.1093/clinids/5.4.758
Source DB: PubMed Journal: Rev Infect Dis ISSN： 0162-0886