Literature DB >> 6352395

Phenylethylamine in neuropsychiatric disorders.

M E Wolf, A D Mosnaim.   

Abstract

Phenylethylamine is an endogenous neuroamine conceptualized as the body's natural amphetamine. PEA has been suggested to play a role in the etiology of several neuropsychiatric disorders. Increased PEA turnover in phenylketonuria contributes to the pathophysiology of this condition. Depressed and chronic paranoid schizophrenic patients show decreased and increased PEA urinary excretion, respectively. Parkinsonian patients show decreased urinary PEA excretion. In animals, drugs that relieve or produce depression and parkinson result in increased or decreased brain PEA levels, respectively. PEA has been postulated to play a role in the etiology of migraine headache and aggression.

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Year:  1983        PMID： 6352395     DOI： 10.1016/0306-3623(83)90020-4

Source DB:  PubMed          Journal:  Gen Pharmacol        ISSN： 0306-3623


  11 in total

1.  An analgesic effect of enkephalinase inhibition is modulated by monoamine oxidase-B and REM sleep deprivations.

Authors:  O E Ukponmwan; J Rupreht; M Dzoljic
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-04       Impact factor: 3.000

2.  Trace amines: identification of a family of mammalian G protein-coupled receptors.

Authors:  B Borowsky; N Adham; K A Jones; R Raddatz; R Artymyshyn; K L Ogozalek; M M Durkin; P P Lakhlani; J A Bonini; S Pathirana; N Boyle; X Pu; E Kouranova; H Lichtblau; F Y Ochoa; T A Branchek; C Gerald
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-17       Impact factor: 11.205

3.  Rat brain-uptake index for phenylethylamine and various monomethylated derivatives.

Authors:  Aron D Mosnaim; Owen H Callaghan; Thomas Hudzik; Marion E Wolf
Journal:  Neurochem Res       Date:  2013-02-07       Impact factor: 3.996

4.  Urinary phenylethylamine correlates positively with hypomania, and negatively with depression, paranoia, and social introversion on the MMPI.

Authors:  H W Moises; P Waldmeier; H Beckmann
Journal:  Eur Arch Psychiatry Neurol Sci       Date:  1986

5.  Analgesic effects of β-phenylethylamine and various methylated derivatives in mice.

Authors:  Aron D Mosnaim; Thomas Hudzik; Marion E Wolf
Journal:  Neurochem Res       Date:  2014-06-26       Impact factor: 3.996

Review 6.  Trace amine-associated receptor 1-Family archetype or iconoclast?

Authors:  David K Grandy
Journal:  Pharmacol Ther       Date:  2007-07-17       Impact factor: 12.310

7.  "TAARgeting Addiction"--The Alamo Bears Witness to Another Revolution: An Overview of the Plenary Symposium of the 2015 Behavior, Biology and Chemistry Conference.

Authors:  David K Grandy; Gregory M Miller; Jun-Xu Li
Journal:  Drug Alcohol Depend       Date:  2015-11-22       Impact factor: 4.492

8.  Neuropharmacological and neurochemical properties of N-(2-cyanoethyl)-2-phenylethylamine, a prodrug of 2-phenylethylamine.

Authors:  G B Baker; R T Coutts; T S Rao
Journal:  Br J Pharmacol       Date:  1987-10       Impact factor: 8.739

Review 9.  Trace Amines and the Trace Amine-Associated Receptor 1: Pharmacology, Neurochemistry, and Clinical Implications.

Authors:  Yue Pei; Aman Asif-Malik; Juan J Canales
Journal:  Front Neurosci       Date:  2016-04-05       Impact factor: 4.677

Review 10.  Novel Molecular Targets of Antidepressants.

Authors:  Małgorzata Jarończyk; Jarosław Walory
Journal:  Molecules       Date:  2022-01-14       Impact factor: 4.411
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