Literature DB >> 635223

Responsiveness of the lamb ductus arteriosus to prostaglandins and their metabolites.

R I Clyman, L Wong, M A Heymann, A M Rudolph.   

Abstract

The relative potencies of the prostaglandins A1, A2, E1, E2, F2alpha and their 15-keto-, 15-keto-13,14-dihydro-, and 13,14-dihydro-metabolites were investigated on isolated lamb ductus arteriosus preparations contracted by exposure to elevated PO2. All the prostaglandins (except PGF2alpha and its 15-keto-metabolites) relaxed the tissue. However, only PGE1, E2, and their 13,14-dihydro-metabolites, were effective at concentrations below 10(-8) M. Therefore, events that alter metabolism of circulating PGs in the perinatal period may have significant effects on the relative patency or closure of the ductus arteriosus.

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Year:  1978        PMID： 635223     DOI： 10.1016/0090-6980(78)90172-7

Source DB:  PubMed          Journal:  Prostaglandins        ISSN： 0090-6980


  3 in total

1.  Finding genetic contributions to sporadic disease: a recessive locus at 12q24 commonly contributes to patent ductus arteriosus.

Authors:  Arya Mani; Seyed-Mahmoud Meraji; Roozbeh Houshyar; Jayaram Radhakrishnan; Alaleh Mani; Mehrabeh Ahangar; Tayebeh M Rezaie; Mohammad-Ali Taghavinejad; Behrooz Broumand; Hongyu Zhao; Carol Nelson-Williams; Richard P Lifton
Journal:  Proc Natl Acad Sci U S A       Date:  2002-10-30       Impact factor: 11.205

Review 2.  Patent ductus arteriosus: experimental aspects.

Authors:  J C Mott
Journal:  Arch Dis Child       Date:  1980-02       Impact factor: 3.791

3.  Syndromic patent ductus arteriosus: evidence for haploinsufficient TFAP2B mutations and identification of a linked sleep disorder.

Authors:  Arya Mani; Jayaram Radhakrishnan; Anita Farhi; Khary S Carew; Carole A Warnes; Carol Nelson-Williams; Ronald W Day; Barbara Pober; Matthew W State; Richard P Lifton
Journal:  Proc Natl Acad Sci U S A       Date:  2005-01-31       Impact factor: 11.205
  3 in total

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