| Literature DB >> 635220 |
Abstract
Three 16-aryloxy analogues of PGF2alpha are potent, full agonists on the isolated rabbit jejunum. Their actions are more prolonged than that of PGF2alpha, and radioactive tracer studies with one of the analogues reveal a slower wash-out of the analogue compared to PGF2alpha, under superfusion conditions. During the prolonged contractile response diminished responses to PGF2alpha were obtained: this effect was investigated in terms of receptor desensitization. The actions of these analogues were also investigated on the isolated guinea-pig ileum and the rabbit oviduct in vivo.Entities:
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Year: 1978 PMID： 635220 DOI： 10.1016/0090-6980(78)90168-5
Source DB: PubMed Journal: Prostaglandins ISSN： 0090-6980