Literature DB >> 6352104

Circulating antibodies to the surface antigens on colon epithelial cells in ulcerative colitis.

T Hibi, S Aiso, M Ishikawa, M Watanabe, T Yoshida, K Kobayashi, H Asakura, S Tsuru, M Tsuchiya.   

Abstract

The fluorescence activated cell sorter (FACS) was used for detecting circulating antibodies to the surface antigens on isolated colon epithelial cells (anti-colon antibodies) by indirect immunofluorescence. Anti-colon antibodies were found in the serum of 30 of 41 (73%) patients with ulcerative colitis. This incidence is much higher than one established in earlier reports by application of indirect immunofluorescence to colon tissue using the fluorescence microscope. The results suggest that FACS analysis is very useful for detecting antibodies to colon specific antigen.

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Year:  1983        PMID： 6352104      PMCID： PMC1536205     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  17 in total

1.  In vitro studies of inflammatory bowel disease. Surface receptors of the mononuclear cell required to lyse allogeneic colonic epithelial cells.

Authors:  J D Stobo; T B Tomasi; K A Huizenga; R J Spencer; R G Shorter
Journal:  Gastroenterology       Date:  1976-02       Impact factor: 22.682

2.  Autoantibodies to colon in rats and human ulcerative colitis: cross reactivity with Escherichia coli O:14 antigen.

Authors:  P Perlmann; S Hammarström; R Lagercrantz; D Campbell
Journal:  Proc Soc Exp Biol Med       Date:  1967-07

3.  Immunological studies in ulcerative colitis. 3. Incidence of antibodies to colon-antigen in ulcerative colitis and other gastro-intestinal diseases.

Authors:  R Lagercrantz; S Hammarström; P Perlmann; B E Gustafsson
Journal:  Clin Exp Immunol       Date:  1966-07       Impact factor: 4.330

4.  Auto-immune reactions in ulcerative colitis.

Authors:  R Wright; S C Truelove
Journal:  Gut       Date:  1966-02       Impact factor: 23.059

5.  Antigen from colon of germfree rats and antibodies in human ulcerative colitis.

Authors:  P Perlmann; S Hammarström; R Lagercrantz; B E Gustafsson
Journal:  Ann N Y Acad Sci       Date:  1965-06-30       Impact factor: 5.691

6.  Demonstration of an assay for specific cytolytic antibody in sera from patients with ulcerative colitis.

Authors:  T Nagai; K M Das
Journal:  Gastroenterology       Date:  1981-06       Impact factor: 22.682

7.  Anti-colon antibody and lymphocytophilic antibody in ulcerative colitis.

Authors:  T Hibi; S Aiso; T Yoshida; M Watanabe; H Asakura; S Tsuru; M Tsuchiya
Journal:  Clin Exp Immunol       Date:  1982-07       Impact factor: 4.330

8.  Isolation and characterization of colonic tissue-bound antibodies from patients with idiopathic ulcerative colitis.

Authors:  K M Das; R Dubin; T Nagai
Journal:  Proc Natl Acad Sci U S A       Date:  1978-09       Impact factor: 11.205

9.  Inflammatory bowel disease associated circulating immune complexes.

Authors:  B J Kemler; E Alpert
Journal:  Gut       Date:  1980-03       Impact factor: 23.059

10.  In vitro studies of ulcerative colitis. I. Reactions of patients' serum with human fetal colon cells in tissue cultures.

Authors:  O BROBERGER; P PERLMANN
Journal:  J Exp Med       Date:  1963-05-01       Impact factor: 14.307
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  21 in total

1.  IgG subclass distribution in serum and rectal mucosa of monozygotic twins with or without inflammatory bowel disease.

Authors:  L Helgeland; C Tysk; G Järnerot; K Kett; E Lindberg; D Danielsson; S N Andersen; P Brandtzaeg
Journal:  Gut       Date:  1992-10       Impact factor: 23.059

Review 2.  Are the inflammatory bowel diseases autoimmune disorders?

Authors:  J Snook
Journal:  Gut       Date:  1990-09       Impact factor: 23.059

3.  Oral immune regulation using colitis extracted proteins for treatment of Crohn's disease: results of a phase I clinical trial.

Authors:  Eran Israeli; Eran Goldin; Oren Shibolet; Athalia Klein; Nilla Hemed; Dean Engelhardt; Elazar Rabbani; Yaron Ilan
Journal:  World J Gastroenterol       Date:  2005-05-28       Impact factor: 5.742

4.  Serum and tissue autoantibodies to colonic epithelium in ulcerative colitis.

Authors:  K M Das
Journal:  Gut       Date:  1991-12       Impact factor: 23.059

5.  Circulating immunoglobulin G1 antibody in patients with ulcerative colitis against the colonic epithelial protein detected by a novel monoclonal antibody.

Authors:  A Dasgupta; A Mandal; K M Das
Journal:  Gut       Date:  1994-12       Impact factor: 23.059

Review 6.  Relationship of extraintestinal involvements in inflammatory bowel disease: new insights into autoimmune pathogenesis.

Authors:  K M Das
Journal:  Dig Dis Sci       Date:  1999-01       Impact factor: 3.199

7.  In vitro anticolon antibody production by mucosal or peripheral blood lymphocytes from patients with ulcerative colitis.

Authors:  T Hibi; M Ohara; K Toda; A Hara; H Ogata; Y Iwao; N Watanabe; M Watanabe; Y Hamada; K Kobayashi
Journal:  Gut       Date:  1990-12       Impact factor: 23.059

8.  Sensitization to epithelial antigens in chronic mucosal inflammatory disease: immunochemical similarity of macromolecules in human colonic epithelium with murine intestinal epithelial cell-associated components (ECAC).

Authors:  J W Paul; K W Kotz; J K Roche
Journal:  Immunology       Date:  1988-12       Impact factor: 7.397

9.  Isolation and characterization of a colonic autoantigen specifically recognized by colon tissue-bound immunoglobulin G from idiopathic ulcerative colitis.

Authors:  F Takahashi; K M Das
Journal:  J Clin Invest       Date:  1985-07       Impact factor: 14.808

10.  Antibodies to a trypsin sensitive pancreatic antigen in chronic inflammatory bowel disease: specific markers for a subgroup of patients with Crohn's disease.

Authors:  F Seibold; P Weber; H Jenss; K H Wiedmann
Journal:  Gut       Date:  1991-10       Impact factor: 23.059
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