Literature DB >> 6352069

Chemical reactivity and mutagenicity of some dihalomethanes.

S Osterman-Golkar, S Hussain, S Walles, B Anderstam, K Sigvardsson.   

Abstract

Four dihalomethanes; dichloromethane, bromochloromethane, dibromomethane and diiodomethane, have been studied with respect to their reactivities towards nucleophilic compounds of different strengths in water solution and with respect to their toxicities and mutagenic effectiveness in bacterial test systems. The correlation between biological activity (toxicity and mutagenic effectiveness in Salmonella TA100) and reactivity towards strong nucleophiles indicates that reactions with nucleophilic groups of high reactivity in the biological material, possibly SH or amino groups in proteins, are involved in their mechanism of action.

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Year:  1983        PMID： 6352069     DOI： 10.1016/0009-2797(83)90011-x

Source DB:  PubMed          Journal:  Chem Biol Interact        ISSN： 0009-2797            Impact factor:   5.192


  3 in total

1.  Results of a short-term toxicity study for three organic chemicals found in Niagara River drinking water.

Authors:  E Komsta; I Chu; V E Secours; V E Valli; D C Villeneuve
Journal:  Bull Environ Contam Toxicol       Date:  1988-10       Impact factor: 2.151

2.  Alkyltransferase-mediated toxicity of bis-electrophiles in mammalian cells.

Authors:  Aley G Kalapila; Anthony E Pegg
Journal:  Mutat Res       Date:  2009-11-24       Impact factor: 2.433

3.  Expression of mammalian glutathione S-transferase 5-5 in Salmonella typhimurium TA1535 leads to base-pair mutations upon exposure to dihalomethanes.

Authors:  R Thier; J B Taylor; S E Pemble; W G Humphreys; M Persmark; B Ketterer; F P Guengerich
Journal:  Proc Natl Acad Sci U S A       Date:  1993-09-15       Impact factor: 11.205
  3 in total

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