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Literature DB >> 6351886

Effect of clofibrate on the growth-kinetics of the murine P 1798(sc) lymphoma.

F M Ubeira, R Seoane, E Puentes, J Faro, B J Regueiro.

Abstract

Clofibrate (CPIB) is a drug applied as an antilipidaemic agent in mammals. In this work we have tested its efficacy in vivo on the growth kinetics of P 1798(sc) lymphoma transplanted to recipient (BALB/c x AKR)F1 mice. Our results show a facilitation of the tumour growth rate in treated recipients. This fact may be related to an effect of the agent on the recipient which produces a decrease in the immune response as was confirmed on testing CPIB on thymus-dependent antigens in haemolytic plaque assays.

Entities: Chemical Disease Species

Mesh：

Substances：
Lipids
Clofibrate

Year: 1983 PMID： 6351886 PMCID： PMC2011464 DOI： 10.1038/bjc.1983.207

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

16 in total

1. IMMUNOLOGY OF SPONTANEOUS MAMMARY CARCINOMAS IN MICE. II. RESISTANCE TO A RAPIDLY AND A SLOWLY DEVELOPING TUMOR.

Authors: M A ATTIA; K B DEOME; D W WEISS
Journal: Cancer Res Date: 1965-05 Impact factor: 12.701

2. EFFECTS OF ALPHA-P-CHLOROPHENOXYISOBUTYRYL ETHYL ESTER (CPIB) WITH AND WITHOUT ANDROSTERONE ON CHOLESTEROL BIOSYNTHESIS IN RAT LIVER.

Authors: D R AVOY; E A SWYRYD; R G GOULD
Journal: J Lipid Res Date: 1965-07 Impact factor: 5.922

Review 10. Drug-induced cancer.

Authors: R Hoover; J F Fraumeni
Journal: Cancer Date: 1981-03-01 Impact factor: 6.860

1 in total

1. Effects of antigen and internal environment on anti-phosphorylcholine immune responses of autoimmune aged NZB/W F1 mice.

Authors: R Seoane; J Faro; A Eiras; I Lareo; J Couceiro; B J Regueiro
Journal: Immunology Date: 1986-06 Impact factor: 7.397

1 in total

Effect of clofibrate on the growth-kinetics of the murine P 1798(sc) lymphoma.

1. IMMUNOLOGY OF SPONTANEOUS MAMMARY CARCINOMAS IN MICE. II. RESISTANCE TO A RAPIDLY AND A SLOWLY DEVELOPING TUMOR.

2. EFFECTS OF ALPHA-P-CHLOROPHENOXYISOBUTYRYL ETHYL ESTER (CPIB) WITH AND WITHOUT ANDROSTERONE ON CHOLESTEROL BIOSYNTHESIS IN RAT LIVER.

3. Response to cortisone and development of cortisone resistance in a cortisone-sensitive lymphosarcoma of the mouse.

4. Effect of clofibrate on plasma proteins including components of the hemostatic mechanism.

5. Correlation between the ability of tumor cells to resist humoral immune attack and their ability to synthesize lipid.

6. Quantitative determination of serum triglycerides by the use of enzymes.

7. Further improvements in the plaque technique for detecting single antibody-forming cells.

8. B cell heterogeneity. II. Transplantation resistance in xid mice which affects the ontogeny of B cell subpopulations.

9. Correlation between lipid synthesis in tumor cells and their sensitivity to humoral immune attack.

Review 10. Drug-induced cancer.

1. Effects of antigen and internal environment on anti-phosphorylcholine immune responses of autoimmune aged NZB/W F1 mice.