Literature DB >> 6351863

Rapid action of Qinghaosu and related drugs on incorporation of [3H]isoleucine by Plasmodium falciparum in vitro.

H M Gu, D C Warhurst, W Peters.   

Abstract

Using the incorporation of [3H]isoleucine into acid-insoluble products as an index of protein-synthetic activity, it was shown that Qinghaosu and two related drugs had a rapid effect on this process in human erythrocytes infected with Plasmodium falciparum in vitro. Inhibition could be seen 1 hr or less after addition of the drugs at concentrations from 5 mumole/1. to 50 nmole/1. It is recommended that the effects of these drugs be studied in cell-free protein-synthetic systems.

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Year:  1983        PMID： 6351863     DOI： 10.1016/0006-2952(83)90002-3

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  7 in total

1.  Bis(benzyl)polyamine analogs inhibit the growth of chloroquine-resistant human malaria parasites (Plasmodium falciparum) in vitro and in combination with alpha-difluoromethylornithine cure murine malaria.

Authors:  A J Bitonti; J A Dumont; T L Bush; M L Edwards; D M Stemerick; P P McCann; A Sjoerdsma
Journal:  Proc Natl Acad Sci U S A       Date:  1989-01       Impact factor: 11.205

Review 2.  New answers through chemotherapy?

Authors:  W Peters
Journal:  Experientia       Date:  1984-12-15

Review 3.  Artemisia annua L.: a source of novel antimalarial drugs.

Authors:  H J Woerdenbag; C B Lugt; N Pras
Journal:  Pharm Weekbl Sci       Date:  1990-10-19

4.  Stage-specific gametocytocidal effect in vitro of the antimalaria drug qinghaosu on Plasmodium falciparum.

Authors:  N Kumar; H Zheng
Journal:  Parasitol Res       Date:  1990       Impact factor: 2.289

5.  In vitro and in vivo studies of the effect of artemether on Schistosoma mansoni.

Authors:  S H Xiao; B A Catto
Journal:  Antimicrob Agents Chemother       Date:  1989-09       Impact factor: 5.191

Review 6.  Antimalarial drugs. An update.

Authors:  D C Warhurst
Journal:  Drugs       Date:  1987-01       Impact factor: 9.546

7.  Antimalarial natural products: a review.

Authors:  Faraz Mojab
Journal:  Avicenna J Phytomed       Date:  2012
  7 in total

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