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Literature DB >> 6351734

Polyoxin D inhibits growth of zoopathogenic fungi.

J M Becker, N L Covert, P Shenbagamurthi, A S Steinfeld, F Naider.

Abstract

We demonstrated that polyoxin D at millimolar concentrations caused marked morphological alterations of the human pathogens Candida albicans and Cryptococcus neoformans. C. albicans incubated in the presence of this drug grew in long chains that were severely swollen. Polyoxin D inhibited the growth of C. neoformans and killed cells of both the yeast and the hyphal phase of C. albicans. These observations give the first evidence that polyoxin antibiotics can kill zoopathogenic fungi.

Entities: Chemical Species

Mesh：

Substances：

Year: 1983 PMID： 6351734 PMCID： PMC185006 DOI： 10.1128/AAC.23.6.926

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

15 in total

1. Molecular aspects of yeast morphogenesis.

Authors: E Cabib
Journal: Annu Rev Microbiol Date: 1975 Impact factor: 15.500

2. Effect of polyoxin D on chitin synthesis and septum formation in Saccharomyces cerevisiae.

Authors: B Bowers; G Levin; E Cabib
Journal: J Bacteriol Date: 1974-08 Impact factor: 3.490

Review 3. Chemotherapy of systemic mycoses (second of two parts).

Authors: J E Bennett
Journal: N Engl J Med Date: 1974-02-07 Impact factor: 91.245

4. Polyoxin D, a competitive inhibitor of UDP-N-acetylglucosamine: chitin N-acetylglucosaminyltransferase in Neurospora crassa.

Authors: A Endo; T Misato
Journal: Biochem Biophys Res Commun Date: 1969-11-06 Impact factor: 3.575

5. Chitin and yeast budding. Properties of chitin synthetase from Saccharomyces carlsbergensis.

Authors: F A Keller; E Cabib
Journal: J Biol Chem Date: 1971-01-10 Impact factor: 5.157

6. Antagonists of an antifungal substance, polyoxin.

Authors: M Mitani; Y Inoue
Journal: J Antibiot (Tokyo) Date: 1968-08 Impact factor: 2.649

Review 7. Ketoconazole: a review of its therapeutic efficacy in superficial and systemic fungal infections.

Authors: R C Heel; R N Brogden; A Carmine; P A Morley; T M Speight; G S Avery
Journal: Drugs Date: 1982 Jan-Feb Impact factor: 9.546

8. An evaluation of two years of clinical experience with ketoconazole.

Authors: J Symoens; M Moens; J Dom; H Scheijgrond; J Dony; V Schuermans; R Legendre; N Finestine
Journal: Rev Infect Dis Date: 1980 Jul-Aug

9. Mechanism of action of the antifugal agent polyoxin D.

Authors: A Endo; K Kakiki; T Misato
Journal: J Bacteriol Date: 1970-10 Impact factor: 3.490

10. Localization of chitin in the cell wall of Candida albicans by means of wheat germ agglutinin. Fluorescence and ultrastructural studies.

Authors: G Tronchin; D Poulain; J Herbaut; J Biguet
Journal: Eur J Cell Biol Date: 1981-12 Impact factor: 4.492

26 in total

1. A 96-well epifluorescence assay for rapid assessment of compounds inhibitory to Candida spp.

Authors: R F Hector; P C Braun
Journal: J Clin Microbiol Date: 1986-10 Impact factor: 5.948

2. An ATP-Dependent Ligase with Substrate Flexibility Involved in Assembly of the Peptidyl Nucleoside Antibiotic Polyoxin.

Authors: Rong Gong; Jianzhao Qi; Pan Wu; You-Sheng Cai; Hongmin Ma; Yang Liu; He Duan; Meng Wang; Zixin Deng; Neil P J Price; Wenqing Chen
Journal: Appl Environ Microbiol Date: 2018-06-18 Impact factor: 4.792

10. Synergistic action of nikkomycins X and Z with papulacandin B on whole cells and regenerating protoplasts of Candida albicans.

Authors: R F Hector; P C Braun
Journal: Antimicrob Agents Chemother Date: 1986-03 Impact factor: 5.191

Polyoxin D inhibits growth of zoopathogenic fungi.

1. Molecular aspects of yeast morphogenesis.

2. Effect of polyoxin D on chitin synthesis and septum formation in Saccharomyces cerevisiae.

Review 3. Chemotherapy of systemic mycoses (second of two parts).

4. Polyoxin D, a competitive inhibitor of UDP-N-acetylglucosamine: chitin N-acetylglucosaminyltransferase in Neurospora crassa.

5. Chitin and yeast budding. Properties of chitin synthetase from Saccharomyces carlsbergensis.

6. Antagonists of an antifungal substance, polyoxin.

Review 7. Ketoconazole: a review of its therapeutic efficacy in superficial and systemic fungal infections.

8. An evaluation of two years of clinical experience with ketoconazole.

9. Mechanism of action of the antifugal agent polyoxin D.

10. Localization of chitin in the cell wall of Candida albicans by means of wheat germ agglutinin. Fluorescence and ultrastructural studies.

1. A 96-well epifluorescence assay for rapid assessment of compounds inhibitory to Candida spp.

2. An ATP-Dependent Ligase with Substrate Flexibility Involved in Assembly of the Peptidyl Nucleoside Antibiotic Polyoxin.

Review 3. Antifungal agents: chemotherapeutic targets and immunologic strategies.

Review 4. Antifungal peptides: novel therapeutic compounds against emerging pathogens.

5. Sensitivity to nikkomycin Z in Candida albicans: role of peptide permeases.

6. Anti-Candida activity of polyoxin: example of peptide transport in yeasts.

7. Evaluation of nikkomycins X and Z in murine models of coccidioidomycosis, histoplasmosis, and blastomycosis.

8. Isolation and characterization of S. cerevisiae mutants deficient in amino acid-inducible peptide transport.

9. Hydrophobic polyoxins are resistant to intracellular degradation in Candida albicans.

10. Synergistic action of nikkomycins X and Z with papulacandin B on whole cells and regenerating protoplasts of Candida albicans.