Literature DB >> 6351060

Control of malaria virulence by alpha 1-acid glycoprotein (orosomucoid), an acute-phase (inflammatory) reactant.

M J Friedman.   

Abstract

During malaria and other infections, the plasma concentration of alpha 1-acid glycoprotein (AGP) increases 3- to 4-fold, but the function of this glycoprotein has been unknown. This study demonstrates, by in vitro culture of the malaria parasite Plasmodium falciparum, that the AGP concentration achieved during malaria is sufficient to inhibit parasite multiplication by 80%. It was found that the inhibitory activity of AGP depends on and is a function of its sialic acid complement (12-16 mol/mol) and its higher-order structure. AGP acts by blocking parasite-erythrocyte interaction during the invasion process. These findings indicate a function for AGP with definite in vivo significance. Moreover, they reveal an important protective response to malaria and perhaps other infectious diseases.

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Year:  1983        PMID： 6351060      PMCID： PMC384268          DOI： 10.1073/pnas.80.17.5421

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  18 in total

1.  Interactions of alpha1-acid glycoprotein with the immune system. I. Purification and effects upon lymphocyte responsiveness.

Authors:  K M Chiu; R F Mortensen; A P Osmand; H Gewurz
Journal:  Immunology       Date:  1977-06       Impact factor: 7.397

2.  Inhibition of platelet aggregation by alpha1-acid glycoprotein.

Authors:  S Snyder; E L Coodley
Journal:  Arch Intern Med       Date:  1976-07

3.  Concentration from continuous culture of erythrocytes infected with trophozoites and schizonts of Plasmodium falciparum.

Authors:  J B Jensen
Journal:  Am J Trop Med Hyg       Date:  1978-11       Impact factor: 2.345

4.  Plasmodium falciparum: assay in vitro for inhibitors of merozoite penetration of erythrocytes.

Authors:  M M Weiss; J D Oppenheim; J P Vanderberg
Journal:  Exp Parasitol       Date:  1981-06       Impact factor: 2.011

5.  The microheterogeneity of human plasma alpha1-acid glycoprotein.

Authors:  E G Berger; S R Wyss; R B Nimberg; K Schmid
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1980-10

6.  Determination of the primary structures of 16 asialo-carbohydrate units derived from human plasma alpha 1-acid glycoprotein by 360-MHZ 1H NMR spectroscopy and permethylation analysis.

Authors:  B Fournet; J Montreuil; G Strecker; L Dorland; J Haverkamp; F G Vliegenthart; J P Binette; K Schmid
Journal:  Biochemistry       Date:  1978-11-28       Impact factor: 3.162

7.  Human malaria parasites in continuous culture.

Authors:  W Trager; J B Jensen
Journal:  Science       Date:  1976-08-20       Impact factor: 47.728

8.  An assay of malaria parasite invasion into human erythrocytes. The effects of chemical and enzymatic modification of erythrocyte membrane components.

Authors:  W V Breuer; H Ginsburg; Z I Cabantchik
Journal:  Biochim Biophys Acta       Date:  1983-01-25

9.  Inhibitory effects of erythrocyte membrane proteins on the in vitro invasion of the human malarial parasite (Plasmodium falciparum) into its host cell.

Authors:  M Perkins
Journal:  J Cell Biol       Date:  1981-09       Impact factor: 10.539

10.  Evidence for differences in erythrocyte surface receptors for the malarial parasites, Plasmodium falciparum and Plasmodium knowlesi.

Authors:  L H Miller; J D Haynes; F M McAuliffe; T Shiroishi; J R Durocher; M H McGinniss
Journal:  J Exp Med       Date:  1977-07-01       Impact factor: 14.307
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  19 in total

1.  Expression of cyclooxygenase-2, alpha 1-acid-glycoprotein and inducible nitric oxide synthase in the developing lesions of murine leprosy.

Authors:  Mayra Silva Miranda; Kendy Wek Rodríguez; Erasmo Martínez Cordero; Oscar Rojas-Espinosa
Journal:  Int J Exp Pathol       Date:  2006-12       Impact factor: 1.925

2.  Structure of the human alpha 1-acid glycoprotein gene: sequence homology with other human acute phase protein genes.

Authors:  L Dente; G Ciliberto; R Cortese
Journal:  Nucleic Acids Res       Date:  1985-06-11       Impact factor: 16.971

3.  Localization of DNA sequences involved in dexamethasone-dependent expression of the rat alpha 1-acid glycoprotein gene.

Authors:  H Baumann; L E Maquat
Journal:  Mol Cell Biol       Date:  1986-07       Impact factor: 4.272

4.  Structure of the rat alpha 1-acid glycoprotein gene.

Authors:  Y C Liao; J M Taylor; J L Vannice; G A Clawson; E A Smuckler
Journal:  Mol Cell Biol       Date:  1985-12       Impact factor: 4.272

5.  The influence of N-acetylneuraminic acid on the properties of human orosomucoid.

Authors:  M L Friedman; J R Wermeling; H B Halsall
Journal:  Biochem J       Date:  1986-05-15       Impact factor: 3.857

6.  Specific protein interacting with a tumor promoter, debromoaplysiatoxin, in bovine serum is alpha 1-acid glycoprotein.

Authors:  H Ueyama; I Sasaki; K Shimomura; M Suganuma
Journal:  J Cancer Res Clin Oncol       Date:  1995       Impact factor: 4.553

7.  Modulation of alpha 1-acid glycoprotein (AGP) gene induction following honey bee venom administration to adjuvant arthritic (AA) rats; possible role of AGP on AA development.

Authors:  M Yiangou; C Konidaris; P Victoratos; L Hadjipetrou-Kourounakis
Journal:  Clin Exp Immunol       Date:  1993-10       Impact factor: 4.330

8.  Antimalarial activities of oligodeoxynucleotide phosphorothioates in chloroquine-resistant Plasmodium falciparum.

Authors:  E Rapaport; K Misiura; S Agrawal; P Zamecnik
Journal:  Proc Natl Acad Sci U S A       Date:  1992-09-15       Impact factor: 11.205

9.  Modulating effects of plasma containing anti-malarial antibodies on in vitro anti-malarial drug susceptibility in Plasmodium falciparum.

Authors:  Preeyaporn Monatrakul; Mathirut Mungthin; Arjen M Dondorp; Srivicha Krudsood; Rachanee Udomsangpetch; Polrat Wilairatana; Nicholas J White; Kesinee Chotivanich
Journal:  Malar J       Date:  2010-11-16       Impact factor: 2.979

10.  Genetic studies of low-abundance human plasma proteins. V. Evidence for a second orosomucoid structural locus (ORM2) expressed in plasma.

Authors:  M H Escallon; R E Ferrell; M I Kamboh
Journal:  Am J Hum Genet       Date:  1987-09       Impact factor: 11.025
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