Primary immune responses to H-Y in BALB/c-H-2k mice.

Female mice of the H-2k haplotype have been thought not to reject primary grafts of male skin. However, most BALB/c-H-2k female mice bred in our colony rejected syngeneic male grafts. Graft rejection was sufficient to prime the mice for the subsequent generation of H-Y-specific cytotoxic T cells and delayed-type hypersensitivity responses.