Literature DB >> 6349579

Neurofilaments in adrenal and extra-adrenal pheochromocytoma. Demonstration using immunofluorescence microscopy.

V P Lehto, I Virtanen, M Miettinen, D Dahl, A Kahri.   

Abstract

Three cases of pheochromocytomas (two adrenal and one retroperitoneal) were studied immunohistologically, using specific antibodies against different types of intermediate filaments. A strong positive reaction was seen in immunofluorescence microscopy with antineurofilament antibodies, while no staining of tumor cells was observed with antikeratin, antivimentin, or antidesmin antibodies. The results are in accordance with the neuroepithelial derivation of adrenal medulla and paraganglia and suggest that antineurofilament antibodies can be used as an adjunct aid in identifying pheochromocytomas.

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Mesh：

Year:  1983        PMID： 6349579

Source DB:  PubMed          Journal:  Arch Pathol Lab Med        ISSN： 0003-9985            Impact factor:   5.534


  6 in total

1.  Expression of neurofilament triplet proteins in human neural tumors. An immunohistochemical study of paraganglioma, ganglioneuroma, ganglioneuroblastoma, and neuroblastoma.

Authors:  M Mukai; C Torikata; H Iri; Y Morikawa; K Shimizu; T Shimoda; N Nukina; Y Ihara; K Kageyama
Journal:  Am J Pathol       Date:  1986-01       Impact factor: 4.307

2.  Coexpression of cytokeratin, neurofilament and vimentin in carcinoid tumors.

Authors:  N Kimura; N Sasano; T Namiki; Y Nakazato
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1989

3.  Synaptophysin: a reliable marker for medulloblastomas.

Authors:  K Schwechheimer; B Wiedenmann; W W Franke
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1987

4.  Immunofluorescence microscopic evaluation of the intermediate filament expression of the adrenal cortex and medulla and their tumors.

Authors:  M Miettinen; V P Lehto; I Virtanen
Journal:  Am J Pathol       Date:  1985-03       Impact factor: 4.307

5.  Multiple peptide production and presence of general neuroendocrine markers detected in 12 cases of human phaeochromocytoma and in mammalian adrenal glands.

Authors:  G W Hacker; A E Bishop; G Terenghi; I M Varndell; J Aghahowa; K Pollard; J Thurner; J M Polak
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1988

6.  Co-expression of cytokeratins and neurofilament proteins in a permanent cell line: cultured rat PC12 cells combine neuronal and epithelial features.

Authors:  W W Franke; C Grund; T Achtstätter
Journal:  J Cell Biol       Date:  1986-11       Impact factor: 10.539
  6 in total

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