Literature DB >> 6348948

A serological test for leprosy with a glycolipid specific for Mycobacterium leprae.

D B Young, T M Buchanan.   

Abstract

A phenolic glycolipid from Mycobacterium leprae was purified and used as antigen in an enzyme-linked immunosorbent assay. Antibodies directed against the lipid were seen in serums from leprosy patients but not in serums from uninfected controls or patients infected with other mycobacteria, including Mycobacterium tuberculosis. The antibody response distinguished between the Mycobacterium leprae lipid and the structurally related phenolic glycolipid from Mycobacterium kansasii. This assay has considerable potential as a specific serodiagnostic test for leprosy infection.

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Year:  1983        PMID： 6348948     DOI： 10.1126/science.6348948

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  38 in total

1.  Novel gelatin particle agglutination test for serodiagnosis of leprosy in the field.

Authors:  S Izumi; T Fujiwara; M Ikeda; Y Nishimura; K Sugiyama; K Kawatsu
Journal:  J Clin Microbiol       Date:  1990-03       Impact factor: 5.948

2.  Results of a World Health Organization-sponsored workshop on monoclonal antibodies to Mycobacterium leprae.

Authors: 
Journal:  Infect Immun       Date:  1985-05       Impact factor: 3.441

3.  Diglycosyl diacylglycerol of Mycobacterium tuberculosis.

Authors:  S W Hunter; M R McNeil; P J Brennan
Journal:  J Bacteriol       Date:  1986-11       Impact factor: 3.490

Review 4.  Biological, chemical, immunological and staining properties of bacteria isolated from tissues of leprosy patients.

Authors:  C Cocito; J Delville
Journal:  Eur J Epidemiol       Date:  1985-09       Impact factor: 8.082

5.  Phenolic glycolipid 1 of Mycobacterium leprae causes nonspecific inflammation but has no effect on cell-mediated responses in mice.

Authors:  S J Brett; C Lowe; S N Payne; P Draper
Journal:  Infect Immun       Date:  1984-12       Impact factor: 3.441

6.  Glycolipids of Mycobacterium tuberculosis strain H37Rv are potential serological markers for diagnosis of active tuberculosis.

Authors:  R P Tiwari; Dileep Tiwari; Sanjay K Garg; Ramesh Chandra; Prakash S Bisen
Journal:  Clin Diagn Lab Immunol       Date:  2005-03

7.  Rational design and evaluation of a multiepitope chimeric fusion protein with the potential for leprosy diagnosis.

Authors:  Malcolm S Duthie; Marah N Hay; Cecile Z Morales; Lauren Carter; Raodoh Mohamath; Lucia Ito; Luiza K M Oyafuso; Marli I P Manini; Marivic V Balagon; Esterlina V Tan; Paul R Saunderson; Steven G Reed; Darrick Carter
Journal:  Clin Vaccine Immunol       Date:  2009-12-16

8.  Serodiagnosis of leprosy: relationships between antibodies to Mycobacterium leprae phenolic glycolipid I and protein antigens.

Authors:  W R Levis; H C Meeker; G B Schuller-Levis; T P Gillis; L J Marino; J Zabriskie
Journal:  J Clin Microbiol       Date:  1986-12       Impact factor: 5.948

9.  Induction of delayed-type hypersensitivity in human volunteers immunized with a candidate leprosy vaccine consisting of killed Mycobacterium leprae.

Authors:  H K Gill; A S Mustafa; T Godal
Journal:  Bull World Health Organ       Date:  1986       Impact factor: 9.408

10.  Cellular and humoral immune response to a phenolic glycolipid antigen (PhenGL-I) in patients with leprosy.

Authors:  F T Koster; D M Scollard; E T Umland; D B Fishbein; W C Hanly; P J Brennan; K E Nelson
Journal:  J Clin Microbiol       Date:  1987-03       Impact factor: 5.948
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