| Literature DB >> 6347081 |
T Masaoka, K Kimura, T Miyazaki, K Sakurada, H Saitoh, M Morioka, N Fujimoto, M Musashi, A Wakui, M Yokoyama, R Kanamaru, M Oguro, T Takagi, C Konda, T Saitoh, I Nakao, S Harashima, Y Ohhashi, Y Sakai, T Sasaki, R Ohno, Y Katoh, K Yamada, Y Hirota, T Takada, A Hoshino, K Ohara, O Kamiya, T Kojima, K Nagata, T Nakamura, M Sasada, T Yonezawa, T Tsubakio, Y Kanayama, T Kitani, N Taniguchi, K Yasunaga, Y Okamoto, H Fujitake, A Ohkubo, A Horiuchi, K Tsubaki, T Takubo, H Shibata, H Kawagoe, M Hirata, T Matsubuchi, K Nagai, S Fujita.
Abstract
A total of 117 cases with hematological malignancies were treated with MCNU at doses of 70-100 mg/m2. Following are the results obtained. 1. MCNU showed a marked depression of cells in the cases with CML, polycythemia vera and thrombocythemia. The low level of cells was maintained for 2 to 7 months. 2. A good response was observed in several cases with blastic crises of CML. 3. No response was observed in two cases with acute leukemia. 4. Although a fair response was observed in several cases with malignant lymphoma or multiple myeloma, moderate bone marrow suppression was observed in a majority of the cases.Entities:
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Year: 1983 PMID： 6347081
Source DB: PubMed Journal: Gan To Kagaku Ryoho ISSN： 0385-0684