Literature DB >> 6347065

Oxidation of two hydroxylated ochratoxin A metabolites by alcohol dehydrogenase.

C Syvertsen, F C Størmer.   

Abstract

(4R)-4-hydroxyochratoxin A, (4S)-4-hydroxyochratoxin A, and 10-hydroxyochratoxin A, all formed from ochratoxin A, were incubated with alcohol dehydrogenase in the presence of NAD. Only (4R)-4-hydroxyochratoxin A and 10-hydroxyochratoxin A acted as substrates for the enzyme. K(m) and turnover number for 10-hydroxyochratoxin A were 110 muM and 0.1 s(-1), respectively.

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Year:  1983        PMID： 6347065      PMCID： PMC242520          DOI： 10.1128/aem.45.5.1701-1703.1983

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  7 in total

1.  Liver alcohol dehydrogenase as a 3-beta-hydroxy-5-beta-cholanic acid dehydrogenase.

Authors:  G Waller; H Theorell; J Sjövall
Journal:  Arch Biochem Biophys       Date:  1965-09       Impact factor: 4.013

2.  Occurrence of ochratoxin A and citrinin in cereals associated with mycotoxic porcine nephropathy.

Authors:  P Krogh; B Hald; E J Pedersen
Journal:  Acta Pathol Microbiol Scand B Microbiol Immunol       Date:  1973-12

3.  DDT metabolism: oxidation of the metabolite 2,2-bis(p-chlorophenyl)ethanol by alcohol dehydrogenase.

Authors:  J E Suggs; R E Hawk; A Curley; E L Boozer; J D McKinney
Journal:  Science       Date:  1970-05-01       Impact factor: 47.728

4.  [Oxidation of allylic alcohols related to vitamin A by horse liver alcohol dehydrogenase].

Authors:  J C Mani; J Dornand
Journal:  C R Acad Hebd Seances Acad Sci D       Date:  1971-06-21

5.  Formation of (4R)- and (4S)-4-hydroxyochratoxin A and 10-hydroxyochratoxin A from Ochratoxin A by rabbit liver microsomes.

Authors:  F C Størmer; O Støren; C E Hansen; J I Pedersen; A J Aasen
Journal:  Appl Environ Microbiol       Date:  1983-04       Impact factor: 4.792

6.  Metabolism of ochratoxin A by rats.

Authors:  O Støren; H Holm; F C Størmer
Journal:  Appl Environ Microbiol       Date:  1982-10       Impact factor: 4.792

7.  Formation of (4R)- and (4S)-4-hydroxyochratoxin A from ochratoxin A by liver microsomes from various species.

Authors:  F C Størmer; C E Hansen; J I Pedersen; G Hvistendahl; A J Aasen
Journal:  Appl Environ Microbiol       Date:  1981-12       Impact factor: 4.792
  7 in total
  1 in total

1.  Time Course of Renal Transcriptomics after Subchronic Exposure to Ochratoxin A in Fisher Rats.

Authors:  Laura Pastor; Ariane Vettorazzi; Elizabeth Guruceaga; López de Cerain A
Journal:  Toxins (Basel)       Date:  2021-02-26       Impact factor: 4.546
  1 in total

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