Literature DB >> 6345033

Dual role of the liver in regulating circulating polymeric IgA in man: studies on patients with liver disease.

K G Chandy, S G Hübscher, E Elias, J Berg, M Khan, D Burnett.   

Abstract

The human liver probably removes circulating polymeric IgA by two routes: (1) secretory component-mediated endocytic transport of polymeric IgA from portal tract blood vessels into bile across biliary epithelial cells and (2) uptake with possible catabolism by hepatocytes and/or sinusoidal phagocytic cells by uncharacterized receptor(s). Failure of either clearance mechanism due to liver disease results in elevated serum polymeric IgA levels. In patients with cholestasis, the raised serum polymeric IgA concentration is due to reflux of biliary secretory immunoglobulin into the blood.

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Year:  1983        PMID： 6345033      PMCID： PMC1535560     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  20 in total

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  8 in total

1.  Hepatic vascular endothelial cells heterogenously express surface antigens associated with monocytes, macrophages and T lymphocytes.

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Journal:  J Physiol Biochem       Date:  2015-04-01       Impact factor: 4.158

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Journal:  Dig Dis Sci       Date:  1997-11       Impact factor: 3.199

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Journal:  Immunology       Date:  1989-12       Impact factor: 7.397

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6.  Contribution of secretory IgA, polymeric IgA and IgA/secretory component-containing circulating immune complexes to the serum hyper-IgA in diabetes mellitus.

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8.  Immunomodulatory Effect of Mangiferin in Experimental Animals with Benzo(a)Pyrene-induced Lung Carcinogenesis.

Authors:  Peramaiyan Rajendran; Thangavel Jayakumar; Ikuo Nishigaki; Ganapathy Ekambaram; Yutaka Nishigaki; Jayabal Vetriselvi; Dhanapal Sakthisekaran
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  8 in total

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