| Literature DB >> 6344337 |
A Laschi, J Descotes, P Tachon, J C Evreux.
Abstract
Male and female mice, IOPS OF1 strain, received an i.p. injection of diazepam 1,2,4 or 8 mg/kg daily for 3 days prior to i.p. challenge with Klebsiella pneumoniae. Diazepam pretreatment increased mortality due to Klebsiella pneumoniae indicating that diazepam alters natural resistance to infection. The mechanism has not been elucidated but would appear to involve T cells and/or macrophages.Entities:
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Year: 1983 PMID： 6344337 DOI： 10.1016/0378-4274(83)90188-1
Source DB: PubMed Journal: Toxicol Lett ISSN： 0378-4274 Impact factor: 4.372