[Blood-brain barrier disorders and changes in intracranial pressure in cats with surgical brain wound following sudded brain decompression].

The condition of the blood-brain barrier and changes in intracranial pressure were studied in cats with surgical brain wounds and after sudded decompression. It was found that evident disturbances of the barrier function appeared only 48 hours after removal of brain tissue and were affecting mainly the white matter. Sudden decompression led to disturbances of blood-brain function when it was proceded by at least 2 hours of epidural compression. Changes developed in the cortex and basal ganglia. After 48 hours from tissue removal a significant rise of pressure was observed in the cisterna magna to a mean value of 11.5 mm Hg. Decompression caused a fall of cerebrospinal pressure, often below zero, and this was followed by a rise to values significantly exceeding the level before decompression.