Literature DB >> 6343996

Systemic and neuropathologic effects of E. coli endotoxin in neonatal dogs.

R S Young, S K Yagel, J Towfighi.   

Abstract

The acute systemic and neuropathologic effects of E. coli endotoxin were determined in neonatal dogs. Administration of sublethal (LD0), moderate (LD50), or lethal (LD100) doses of endotoxin produced significant arterial hypotension, metabolic (lactic) acidosis, and hypoglycemia. Neuropathologic changes consisted of widespread inflammation in both grey and white matter; however, necrotic lesions were found only in forebrain white matter.

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Year:  1983        PMID： 6343996     DOI： 10.1203/00006450-198305000-00008

Source DB:  PubMed          Journal:  Pediatr Res        ISSN： 0031-3998            Impact factor:   3.756


  11 in total

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Review 9.  Intrauterine infection/inflammation during pregnancy and offspring brain damages: possible mechanisms involved.

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