Literature DB >> 634381

Muscle relaxant properties of the identified metabolites of dantrolene.

K O Ellis, F L Wessels.   

Abstract

Identified metabolites of dantrolene, a skeletal muscle relaxant, were studied for inhibition of skeletal muscle contractions. Inhibition of muscle contractions were studied in vivo in the rat gastrocnemius muscle preparation, and in vitro using isolated rat diaphragm strips. Dantrolene (D) and 5-hydroxydantrolene (5-HD) inhibited muscle contraction responses in a dose dependent manner, both in vivo and in vitro. 5-HD was less potent than D.

Entities:  

Mesh：

Substances：

Year:  1978        PMID： 634381     DOI： 10.1007/bf00507042

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  13 in total

1.  TOPICAL PHARMACOLOGY AND TOXICOLOGY OF DIMETHYL SULFOXIDE. 1.

Authors:  A M KLIGMAN
Journal:  JAMA       Date:  1965-09-06       Impact factor: 56.272

2.  DIMETHYL SULFOXIDE. 2.

Authors:  A M KLIGMAN
Journal:  JAMA       Date:  1965-09-13       Impact factor: 56.272

3.  A comparison of skeletal, cardiac, and smooth muscle actions of dantrolene sodium--a skeletal muscle relaxant.

Authors:  K O Ellis; J L Butterfield; F L Wessels; J F Carpenter
Journal:  Arch Int Pharmacodyn Ther       Date:  1976-11

4.  Studies on the mechanism of action of dantrolene sodium. A skeletal muscle relaxant.

Authors:  K O Ellis; J F Carpenter
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1972       Impact factor: 3.000

5.  A comparative study of dantrolene sodium and other skeletal muscle relaxants with the Straub tail mouse.

Authors:  K O Ellis; J F Carpenter
Journal:  Neuropharmacology       Date:  1974-03       Impact factor: 5.250

6.  Pharmacology of dantrolene sodium in children.

Authors:  P S Lietman; R H Haslam; J R Walcher
Journal:  Arch Phys Med Rehabil       Date:  1974-08       Impact factor: 3.966

7.  The effect of DMSO on percutaneous penetration of hydrocortisone and testosterone in man.

Authors:  H I Maibach; R J Feldmann
Journal:  Ann N Y Acad Sci       Date:  1967-03-15       Impact factor: 5.691

8.  Quantitative determination of dantrolene sodium and its metabolites by differential pulse polarography.

Authors:  P L Cox; J P Heotis; D Polin; G M Rose
Journal:  J Pharm Sci       Date:  1969-08       Impact factor: 3.534

9.  Synthesis of 5-hydroxy-1-((5-(p-nitrophenyl)furfurylidene)-amino) hydantoin, a metabolite of dantrolene.

Authors:  R L White; T J Schwan
Journal:  J Pharm Sci       Date:  1976-01       Impact factor: 3.534

10.  Effect of dimethylsulfoxide on isolated-innervated skeletal, smooth, and cardiac muscle.

Authors:  W M Sams; N V Carroll; P L Crantz
Journal:  Proc Soc Exp Biol Med       Date:  1966-05
View more
  5 in total

Review 1.  Dantrolene.

Authors:  B A Britt
Journal:  Can Anaesth Soc J       Date:  1984-01

Review 2.  Spasticity and drug therapy.

Authors:  E W Wuis
Journal:  Pharm Weekbl Sci       Date:  1987-10-16

3.  Relationship between plasma concentration and effect of dantrolene sodium in man.

Authors:  W J Meyler; H W Mols-Thürkow; H Wesseling
Journal:  Eur J Clin Pharmacol       Date:  1979-09       Impact factor: 2.953

Review 4.  Dantrolene. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in malignant hyperthermia, the neuroleptic malignant syndrome and an update of its use in muscle spasticity.

Authors:  A Ward; M O Chaffman; E M Sorkin
Journal:  Drugs       Date:  1986-08       Impact factor: 9.546

Review 5.  Dantrolene: mechanisms of neuroprotection and possible clinical applications in the neurointensive care unit.

Authors:  Susanne Muehlschlegel; John R Sims
Journal:  Neurocrit Care       Date:  2008-08-12       Impact factor: 3.532
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.