Literature DB >> 6343799

Two pathways of division inhibition in UV-irradiated E. coli.

P Burton, I B Holland.   

Abstract

We have investigated the mechanism of division inhibition in E. coli following UV-irradiation or nalidixic acid treatment. After UV, two separate mechanisms, both dependent upon recA, appear to block division. One mechanism is dependent upon sfiA and sfiB, is inhibited by low levels (4 micrograms/ml) of rifamycin and is expressed in tif mutants at 42 degrees C. The second mechanism is dependent on sfiA, B, is resistant to rifamycin and does not occur in cells lacking DNA replication forks. We suggest that this second mechanism is the result of the failure to terminate DNA replication in inhibited cells. Nalidixic acid inhibition of cell division also appears to involve both mechanisms but as found previously replication forks are also necessary to induce the sfi pathway.

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Year:  1983        PMID： 6343799     DOI： 10.1007/bf00330334

Source DB:  PubMed          Journal:  Mol Gen Genet        ISSN： 0026-8925


  21 in total

1.  Growth rate and generation time of bacteria, with special reference to continuous culture.

Authors:  E O POWELL
Journal:  J Gen Microbiol       Date:  1956-12

2.  Cell division during inhibition of deoxyribonucleic acid synthesis in Escherichia coli.

Authors:  C E Helmstetter; O Pierucci
Journal:  J Bacteriol       Date:  1968-05       Impact factor: 3.490

3.  The radiation sensitivity of Escherichia coli B: a hypothesis relating filament formation and prophage induction.

Authors:  E M Witkin
Journal:  Proc Natl Acad Sci U S A       Date:  1967-05       Impact factor: 11.205

4.  Model for regulation of Escherichia coli DNA repair functions.

Authors:  L J Gudas; A B Pardee
Journal:  Proc Natl Acad Sci U S A       Date:  1975-06       Impact factor: 11.205

Review 5.  Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli.

Authors:  E M Witkin
Journal:  Bacteriol Rev       Date:  1976-12

6.  Evidence for the inducibility of the uvrB operon.

Authors:  M Fogliano; P F Schendel
Journal:  Nature       Date:  1981-01-15       Impact factor: 49.962

7.  Further characterization of sfiA and sfiB mutations in Escherichia coli.

Authors:  O Huisman; R D'Ari; J George
Journal:  J Bacteriol       Date:  1980-10       Impact factor: 3.490

8.  Isolation and characterization of amber mutations in the lexA gene of Escherichia coli K-12.

Authors:  L Z Pacelli; S H Edmiston; D W Mount
Journal:  J Bacteriol       Date:  1979-01       Impact factor: 3.490

9.  Cleavage of the Escherichia coli lexA protein by the recA protease.

Authors:  J W Little; S H Edmiston; L Z Pacelli; D W Mount
Journal:  Proc Natl Acad Sci U S A       Date:  1980-06       Impact factor: 11.205

10.  Expression of the E. coli uvrA gene is inducible.

Authors:  C J Kenyon; G C Walker
Journal:  Nature       Date:  1981-02-26       Impact factor: 49.962
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  13 in total

1.  Chromosome segregation and cell division defects in recBC sbcBC ruvC mutants of Escherichia coli.

Authors:  D Zahradka; K Vlahović; M Petranović; D Petranović
Journal:  J Bacteriol       Date:  1999-10       Impact factor: 3.490

2.  Inhibition of cell division in hupA hupB mutant bacteria lacking HU protein.

Authors:  A M Dri; J Rouviere-Yaniv; P L Moreau
Journal:  J Bacteriol       Date:  1991-05       Impact factor: 3.490

3.  A replication-inhibited unsegregated nucleoid at mid-cell blocks Z-ring formation and cell division independently of SOS and the SlmA nucleoid occlusion protein in Escherichia coli.

Authors:  Joshua Cambridge; Alexandra Blinkova; David Magnan; David Bates; James R Walker
Journal:  J Bacteriol       Date:  2013-10-18       Impact factor: 3.490

4.  Escherichia coli parA is an allele of the gyrB gene.

Authors:  J Kato; Y Nishimura; H Suzuki
Journal:  Mol Gen Genet       Date:  1989-05

5.  Genetic and morphological characterization of ftsB and nrdB mutants of Escherichia coli.

Authors:  P E Taschner; J G Verest; C L Woldringh
Journal:  J Bacteriol       Date:  1987-01       Impact factor: 3.490

6.  Structural inhibition and reactivation of Escherichia coli septation by elements of the SOS and TER pathways.

Authors:  A Dopazo; A Tormo; M Aldea; M Vicente
Journal:  J Bacteriol       Date:  1987-04       Impact factor: 3.490

7.  Bacillus subtilis cell cycle as studied by fluorescence microscopy: constancy of cell length at initiation of DNA replication and evidence for active nucleoid partitioning.

Authors:  M E Sharpe; P M Hauser; R G Sharpe; J Errington
Journal:  J Bacteriol       Date:  1998-02       Impact factor: 3.490

8.  Overproduction of FtsZ suppresses sensitivity of lon mutants to division inhibition.

Authors:  J Lutkenhaus; B Sanjanwala; M Lowe
Journal:  J Bacteriol       Date:  1986-06       Impact factor: 3.490

9.  holE, the gene coding for the theta subunit of DNA polymerase III of Escherichia coli: characterization of a holE mutant and comparison with a dnaQ (epsilon-subunit) mutant.

Authors:  S C Slater; M R Lifsics; M O'Donnell; R Maurer
Journal:  J Bacteriol       Date:  1994-02       Impact factor: 3.490

10.  Cell-division control in Escherichia coli: specific induction of the SOS function SfiA protein is sufficient to block septation.

Authors:  O Huisman; R D'Ari; S Gottesman
Journal:  Proc Natl Acad Sci U S A       Date:  1984-07       Impact factor: 11.205
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