Literature DB >> 6343429

Subsets of lymphoid cells in blood and thymus in myasthenia gravis. Monoclonal antibody analysis.

N Fujii, Y Itoyama, T Tabira, Y Kuroiwa.   

Abstract

Lymphoid cell subpopulations in peripheral blood and thymus were analyzed in patients with myasthenia gravis (MG) using monoclonal antibodies. The proportion of lymphocytes of T lineage (OKT 3+, OKT 4+, OKT 8+ cells) in peripheral blood of 11 MG patients, was significantly decreased in comparison with controls, but the ratio of OKT 4+/OKT 8+ cells was not different. Thymus cells were studied in 9 patients. The percentage of OKIa 1+ cells was significantly higher in MG thymus than in control thymus (P less than 0.0005). There were no significant differences in the proportions of T lymphocyte subsets between MG and control thymuses.

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Year:  1983        PMID： 6343429     DOI： 10.1016/0165-5728(83)90031-0

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  6 in total

1.  Intrathymic lymphoid cell differentiation in myasthenia gravis: an immunophenotypic study.

Authors:  M F Ferrio; L Durelli; U Massazza; R Cavallo; G Poccardi; G Maggi; C Casadio; M Di Summa; L Bergamini
Journal:  Ital J Neurol Sci       Date:  1991-12

2.  Individual germinal centres of myasthenia gravis human thymuses contain polyclonal activated B cells that express all the Vh and Vk families.

Authors:  V Guigou; D Emilie; S Berrih-Aknin; F Fumoux; M Fougereau; C Schiff
Journal:  Clin Exp Immunol       Date:  1991-02       Impact factor: 4.330

3.  Thymectomy in myasthenia with pure ocular symptoms.

Authors:  F Schumm; H Wiethölter; A Fateh-Moghadam; J Dichgans
Journal:  J Neurol Neurosurg Psychiatry       Date:  1985-04       Impact factor: 10.154

4.  Studies on the thymus of non-obese diabetic (NOD) mice: effect of transgene expression.

Authors:  L A O'Reilly; D Healey; E Simpson; P Chandler; T Lund; M A Ritter; A Cooke
Journal:  Immunology       Date:  1994-06       Impact factor: 7.397

5.  Thymic B lymphocyte clones from patients with myasthenia gravis secrete monoclonal striational autoantibodies reacting with myosin, alpha actinin, or actin.

Authors:  C L Williams; V A Lennon
Journal:  J Exp Med       Date:  1986-10-01       Impact factor: 14.307

6.  Unusual phenotype of B cells in the thymus of normal mice.

Authors:  M Miyama-Inaba; S Kuma; K Inaba; H Ogata; H Iwai; R Yasumizu; S Muramatsu; R M Steinman; S Ikehara
Journal:  J Exp Med       Date:  1988-08-01       Impact factor: 14.307
  6 in total

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