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Literature DB >> 6343355

Nonsense mutations in the can1 locus of Saccharomyces cerevisiae.

Abstract

Yeast mutants resistant to L-canavanine were selected. All were recessive and fell into the can1 complementation group. Nonsense mutations were identified among them by using a set of different suppressors. Frequencies of UAA, UAG, and presumed UGA mutations were 14.8, 0.8, and 0.4%, respectively. A high incidence of nonsense mutations having discriminatory suppression patterns was characteristic of the locus.

Entities: Chemical Gene Species

Mesh：

Substances：
Canavanine

Year: 1983 PMID： 6343355 PMCID： PMC217629 DOI： 10.1128/jb.154.3.1476-1479.1983

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

20 in total

1. Genetic and physiological characterization of met15 mutants of Saccharomyces cerevisiae: a selective system for forward and reverse mutations.

Authors: A Singh; F Sherman
Journal: Genetics Date: 1975-09 Impact factor: 4.562

2. Isolation and characterization of amber suppressors in yeast.

Authors: S W Liebman; F Sherman; J W Stewart
Journal: Genetics Date: 1976-02 Impact factor: 4.562

3. Yeast UAA suppressors effective in psi+ strains serine-inserting suppressors.

Authors: B I Ono; J W Stewart; F Sherman
Journal: J Mol Biol Date: 1979-02-15 Impact factor: 5.469

Review 4. Suppressors in yeast.

Authors: D C Hawthorne; U Leupold
Journal: Curr Top Microbiol Immunol Date: 1974 Impact factor: 4.291

5. Yeast UAA suppressors effective in psi+ strains: leucine-inserting suppressors.

Authors: B I Ono; J W Stewart; F Sherman
Journal: J Mol Biol Date: 1979-08-15 Impact factor: 5.469

6. Amino acid replacements resulting from super-suppression of nonsense mutants of iso-1-cytochrome c from yeast.

Authors: R A Gilmore; J W Stewart; F Sherman
Journal: J Mol Biol Date: 1971-10-14 Impact factor: 5.469

7. Allelic Complementation in the First Gene for Histidine Biosynthesis in SACCHAROMYCES CEREVISIAE. I. Characteristics of Mutants and Genetic Mapping of Alleles.

Authors: C T Korch; R Snow
Journal: Genetics Date: 1973-06 Impact factor: 4.562

8. Genetic Mapping in Saccharomyces IV. Mapping of Temperature-Sensitive Genes and Use of Disomic Strains in Localizing Genes.

Authors: R K Mortimer; D C Hawthorne
Journal: Genetics Date: 1973-05 Impact factor: 4.562

Nonsense mutations in the can1 locus of Saccharomyces cerevisiae.

1. Genetic and physiological characterization of met15 mutants of Saccharomyces cerevisiae: a selective system for forward and reverse mutations.

2. Isolation and characterization of amber suppressors in yeast.

3. Yeast UAA suppressors effective in psi+ strains serine-inserting suppressors.

Review 4. Suppressors in yeast.

5. Yeast UAA suppressors effective in psi+ strains: leucine-inserting suppressors.

6. Amino acid replacements resulting from super-suppression of nonsense mutants of iso-1-cytochrome c from yeast.

7. Allelic Complementation in the First Gene for Histidine Biosynthesis in SACCHAROMYCES CEREVISIAE. I. Characteristics of Mutants and Genetic Mapping of Alleles.

8. Genetic Mapping in Saccharomyces IV. Mapping of Temperature-Sensitive Genes and Use of Disomic Strains in Localizing Genes.

9. Identification and nucleotide sequence of the sup8-e UGA-suppressor leucine tRNA from Schizosaccharomyces pombe.

10. The CAN1 locus of Saccharomyces cerevisiae: fine-structure analysis and forward mutation rates.

1. UGA suppressors in Saccharomyces cerevisiae: allelism, action spectra and map positions.

2. The yeast PH domain proteins Slm1 and Slm2 are targets of sphingolipid signaling during the response to heat stress.

3. The shuttling protein Npl3 promotes translation termination accuracy in Saccharomyces cerevisiae.