Literature DB >> 6343094

Are "natural killer" cells involved in allograft rejection?

A Nemlander, E Saksela, P Häyry.   

Abstract

"Natural killer" (NK) effector cells and large granular lymphocytes (LGL) are found inside rat renal allografts during rejection. Their appearance in situ precedes the appearance of cytotoxic T lymphocytes, and concomitantly with their influx in the allograft, the NK activity and the LGL are depleted from the recipient spleen. This suggests that the NK effector cells and the LGL are involved in allograft rejection, although their role(s) among the other in situ inflammatory effector pathways remains to be clarified.

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Year:  1983        PMID： 6343094     DOI： 10.1002/eji.1830130415

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  15 in total

1.  Natural killer cells in normal pregnancy: analysis using monoclonal antibodies and single-cell cytotoxicity assays.

Authors:  C D Gregory; H Lee; G B Rees; I V Scott; L P Shah; P R Golding
Journal:  Clin Exp Immunol       Date:  1985-10       Impact factor: 4.330

2.  Natural killer-cell activity in cyclosporine-treated renal allograft recipients.

Authors:  M Lefkowitz; J Kornbluth; J E Tomaszewski; D K Jorkasky
Journal:  J Clin Immunol       Date:  1988-03       Impact factor: 8.317

3.  Cell populations in the human early pregnancy decidua: natural killer activity and response to interleukin-2 of CD56-positive large granular lymphocytes.

Authors:  B L Ferry; P M Starkey; I L Sargent; G M Watt; M Jackson; C W Redman
Journal:  Immunology       Date:  1990-08       Impact factor: 7.397

4.  Expression and function of alpha 4/beta 7 integrin on human natural killer cells.

Authors:  J J Pérez-Villar; J M Zapata; I Melero; A Postigo; E Sánchez-Madrid; M López-Botet
Journal:  Immunology       Date:  1996-09       Impact factor: 7.397

5.  Short-term lymphokine stimulation of human peripheral blood mononuclear cells generates cytolytic activity against endothelial cells: involvement of natural killer cells.

Authors:  A M Miltenburg; M E Meijer-Paape; M R Daha; L C Paul
Journal:  Immunology       Date:  1988-09       Impact factor: 7.397

6.  Large agranular lymphocytes: early non-specific effector cells in allograft rejection in the mouse.

Authors:  C D Gregory; M E Atkinson
Journal:  Immunology       Date:  1984-10       Impact factor: 7.397

7.  Natural killer-cell activity, interferon-alpha 2 production, and interleukin-2 production in cyclosporine-treated and conventionally immunosuppressed human allograft recipients.

Authors:  P J Guillou; G R Giles; C W Ramsden
Journal:  J Clin Immunol       Date:  1986-09       Impact factor: 8.317

8.  Experimental studies of immunologically mediated enteropathy. II. Role of natural killer cells in the intestinal phase of murine graft-versus-host reaction.

Authors:  A M Mowat; M V Felstein
Journal:  Immunology       Date:  1987-06       Impact factor: 7.397

9.  Renal allograft rejection: protection of renal epithelium from natural killer cells by cytokine-induced up-regulation of class I major histocompatibility antigens.

Authors:  Y Lin; G Proud; R M Taylor; J A Kirby
Journal:  Immunology       Date:  1993-06       Impact factor: 7.397

10.  Phenotypic and functional characterization of lymphocytes that bind human microvascular endothelial cells in vitro. Evidence for preferential binding of natural killer cells.

Authors:  J R Bender; R Pardi; M A Karasek; E G Engleman
Journal:  J Clin Invest       Date:  1987-06       Impact factor: 14.808
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