Literature DB >> 6342138

Glucose stimulation of the antilipolytic effect of insulin in humans.

P Arner, J Bolinder, J Ostman.   

Abstract

Dose-response studies of the inhibition of lipolysis by insulin in isolated human adipocytes were conducted with the use of a sensitive bioluminescent assay of glycerol release. The addition of glucose to the incubation medium was associated with an increase in insulin sensitivity and an increase in the maximum insulin effect. The results suggest that glucose plays an important role in regulating the antilipolytic action of insulin in humans.

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Year:  1983        PMID： 6342138     DOI： 10.1126/science.6342138

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  4 in total

Review 1.  Insulin receptor- and nonreceptor-controlled cellular substrate processing. A review of clinical studies in the isolated human adipocyte model.

Authors:  O Pedersen
Journal:  J Endocrinol Invest       Date:  1985-02       Impact factor: 4.256

2.  Lipolysis during fasting. Decreased suppression by insulin and increased stimulation by epinephrine.

Authors:  M D Jensen; M W Haymond; J E Gerich; P E Cryer; J M Miles
Journal:  J Clin Invest       Date:  1987-01       Impact factor: 14.808

3.  Insulin action in human adipose tissue in acromegaly.

Authors:  J Bolinder; J Ostman; S Werner; P Arner
Journal:  J Clin Invest       Date:  1986-04       Impact factor: 14.808

4.  Influence of obesity on the antilipolytic effect of insulin in isolated human fat cells obtained before and after glucose ingestion.

Authors:  P Arner; J Bolinder; P Engfeldt; J Hellmér; J Ostman
Journal:  J Clin Invest       Date:  1984-03       Impact factor: 14.808
  4 in total

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