Literature DB >> 6341592

Immunological tolerance induced by in utero injection.

R D Barnes, B E Pottinger, J Marston, P Flecknell, R H Ward, S Kalter, R L Heberling.   

Abstract

Intrauterine injection of human whole blood into rabbit and rhesus monkey fetuses was found to result in long lasting unresponsiveness to human serum albumin. Intrauterine injection of viable allogeneic bone marrow cells into rabbit fetuses was without any apparent harmful effect and also resulted in permanent unresponsiveness demonstrated by donor red cell survival studies. The implication of these findings in respect of using this approach towards the correction of certain inherited diseases in man is discussed.

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Year:  1983        PMID： 6341592      PMCID： PMC1048984          DOI： 10.1136/jmg.20.1.41

Source DB:  PubMed          Journal:  J Med Genet        ISSN： 0022-2593            Impact factor:   6.318


  14 in total

1.  Tolerance in early embryo aggregation (EEA) derived mouse chimeras.

Authors:  R D Barnes
Journal:  Transplant Proc       Date:  1976-09       Impact factor: 1.066

2.  IMMUNOLOGICAL UNRESPONSIVENESS TO PROTEIN ANTIGENS IN RABBITS. II. THE NATURE OF THE SUBSEQUENT ANTIBODY RESPONSE.

Authors:  J H HUMPHREY
Journal:  Immunology       Date:  1964-07       Impact factor: 7.397

3.  Immunological effects of experimental embryonal parabiosis.

Authors:  M HASEK; T HRABA
Journal:  Nature       Date:  1955-04-30       Impact factor: 49.962

4.  A simple method for inducing tolerance of skin homografts in mice.

Authors:  R E BILLINGHAM; L BRENT
Journal:  Transplant Bull       Date:  1957-04

5.  Acquired immune tolerance to human albumin and the response to subsequent injections of diazo human albumin.

Authors:  B CINADER; J M DUBERT
Journal:  Br J Exp Pathol       Date:  1955-10

6.  Inhibition of antibody formation in mature rabbits by contact with the antigen at an early age.

Authors:  R HANAN; J OYAMA
Journal:  J Immunol       Date:  1954-07       Impact factor: 5.422

7.  Actively acquired tolerance of foreign cells.

Authors:  R E BILLINGHAM; L BRENT; P B MEDAWAR
Journal:  Nature       Date:  1953-10-03       Impact factor: 49.962

8.  Fate of antibody following in vivo combination with specific antigen.

Authors:  F J DIXON; P H MAURER
Journal:  Proc Soc Exp Biol Med       Date:  1953-11

9.  Obstetric aspects of midtrimester fetal blood sampling by needling or fetoscopy.

Authors:  D V Fairweather; R H Ward; B Modell
Journal:  Br J Obstet Gynaecol       Date:  1980-02

10.  Immunologic unresponsiveness induced by protein antigens.

Authors:  F J DIXON; P H MAUER
Journal:  J Exp Med       Date:  1955-03-01       Impact factor: 14.307
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  1 in total

1.  Long-term repopulating ability of xenogeneic transplanted human fetal liver hematopoietic stem cells in sheep.

Authors:  E D Zanjani; A W Flake; H Rice; M Hedrick; M Tavassoli
Journal:  J Clin Invest       Date:  1994-03       Impact factor: 14.808
  1 in total

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