Literature DB >> 634046

The metabolism of lithocholic acid-3alpha-sulfate by human intestinal microflora.

M I Kelsey, G M Muschik, S A Sexton.   

Abstract

Lithocholic acid-3alpha-sulfate is metabolized by human intestinal microflora to nonpolar metabolites which have been partially purified by Sephadex LH-20 chromatography. These metabolites were characterized by thin layer and gas liquid chromatography as well as combined gas liquid chromatography-mass spectrometry. The chromatographic properties of one of the metabolites are consistent with those described for a delta2- or delta3-cholenate. The formation of cholenates by the microflora may represent a retoxification of the sulfate ester of lithocholic acid.

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Year:  1978        PMID： 634046     DOI： 10.1007/bf02533258

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.880


  22 in total

1.  The biosynthesis of ethyl lithocholate by fecal microorganisms.

Authors:  M I Kelsey; R J Thompson
Journal:  J Steroid Biochem       Date:  1976-02       Impact factor: 4.292

2.  Bile acids: co-mutagenic activity in the Salmonella-mammalian-microsome mutagenicity test: brief communication.

Authors:  S J Silverman; A W Andrews
Journal:  J Natl Cancer Inst       Date:  1977-11       Impact factor: 13.506

3.  Bacterial metabolization of taurolithocholic acid 3-alpha-sulfate.

Authors:  A Bremmelgaard; A Bremmelgaard
Journal:  Acta Pathol Microbiol Scand B Microbiol Immunol       Date:  1974-08

4.  The effect of bile on the induction of experimental intestinal tumors in rats.

Authors:  C Chomchai; N Bhadrachari; N D Nigro
Journal:  Dis Colon Rectum       Date:  1974 May-Jun       Impact factor: 4.585

5.  Effect of lithocholic acid on DL-ethionine carcinogenesis in rat liver.

Authors:  Y Hiasa; Y Konishi; Y Kamamoto; T Watanabe; N Ito
Journal:  Gan       Date:  1971-08

6.  Semiquantitative measurement of lithocholic acid compounds in bile from patients with gallstones, before and during treatment with chenodeoxycholic acid.

Authors:  T Arnfred; L Pedersen
Journal:  Scand J Gastroenterol       Date:  1976       Impact factor: 2.423

7.  Sulfation and renal excretion of bile salts in patients with cirrhosis of the liver.

Authors:  A Stiehl; D L Earnest; W H Admirant
Journal:  Gastroenterology       Date:  1975-03       Impact factor: 22.682

8.  Impaired lithocholate sulfation in the rhesus monkey: a possible mechanism for chenodeoxycholate toxicity.

Authors:  T R Gadacz; R N Allan; E Mack; A F Hofmann
Journal:  Gastroenterology       Date:  1976-06       Impact factor: 22.682

9.  Isolation and purification of lithocholic acid metabolites produced by the intestinal microflora.

Authors:  M I Kelsey; S A Sexton
Journal:  J Chromatogr       Date:  1977-03-21

10.  Hydrolysis of lithocholate sulfate by Pseudomonas aeruginosa.

Authors:  T J Imperato; C G Wong; L J Chen; R J Bolt
Journal:  J Bacteriol       Date:  1977-04       Impact factor: 3.490
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  3 in total

1.  The metabolism of lithocholic acid and lithocholic acid-3-alpha-sulfate by human fecal bacteria.

Authors:  S P Borriello; R W Owen
Journal:  Lipids       Date:  1982-07       Impact factor: 1.880

2.  Formation of delta 2- and delta 3-cholenoic acids from bile acid 3-sulfates by a human intestinal Fusobacterium strain.

Authors:  J Robben; G Janssen; R Merckx; H Eyssen
Journal:  Appl Environ Microbiol       Date:  1989-11       Impact factor: 4.792

3.  Analysis and structure determination of unsaturated 5 beta - cholanoic acids.

Authors:  A Kuksis; P Child
Journal:  Lipids       Date:  1980-09       Impact factor: 1.880
  3 in total

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