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Literature DB >> 6339954

The yeast tRNATyr gene intron is essential for correct modification of its tRNA product.

Abstract

Precise deletion of the intervening sequence of a yeast tRNATyr ochre suppressor gene (SUP6) significantly reduced its suppressor activity relative to that of the unaltered gene. This is probably the result of the absence of the pseudouridine modification, normally present at the middle anticodon position of mature suppressor tRNA, in tRNA synthesized in vivo from the deleted gene.

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Year: 1983 PMID： 6339954 DOI： 10.1038/302681a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

64 in total

1. Complete 5' and 3' end maturation of group II intron-containing tRNA precursors.

Authors: J Vogel; W R Hess
Journal: RNA Date: 2001-02 Impact factor: 4.942

2. Translational nonsense codon suppression as indicator for functional pre-tRNA splicing in transformed Arabidopsis hypocotyl-derived calli.

Authors: Kazuhito Akama; Hildburg Beier
Journal: Nucleic Acids Res Date: 2003-02-15 Impact factor: 16.971

3. Identity elements for N2-dimethylation of guanosine-26 in yeast tRNAs.

Authors: J Edqvist; H Grosjean; K B Stråby
Journal: Nucleic Acids Res Date: 1992-12-25 Impact factor: 16.971

4. Plant nonsense suppressor tRNA(Tyr) genes are expressed at very low levels in vitro due to inefficient splicing of the intron-containing pre-tRNAs.

Authors: Z Szweykowska-Kulinska; H Beier
Journal: Nucleic Acids Res Date: 1991-02-25 Impact factor: 16.971

5. Transcription factor IIIB generates extended DNA interactions in RNA polymerase III transcription complexes on tRNA genes.

Authors: G A Kassavetis; D L Riggs; R Negri; L H Nguyen; E P Geiduschek
Journal: Mol Cell Biol Date: 1989-06 Impact factor: 4.272

The yeast tRNATyr gene intron is essential for correct modification of its tRNA product.

1. Complete 5' and 3' end maturation of group II intron-containing tRNA precursors.

2. Translational nonsense codon suppression as indicator for functional pre-tRNA splicing in transformed Arabidopsis hypocotyl-derived calli.

3. Identity elements for N2-dimethylation of guanosine-26 in yeast tRNAs.

4. Plant nonsense suppressor tRNA(Tyr) genes are expressed at very low levels in vitro due to inefficient splicing of the intron-containing pre-tRNAs.

5. Transcription factor IIIB generates extended DNA interactions in RNA polymerase III transcription complexes on tRNA genes.

6. Bringing order to translation: the contributions of transfer RNA anticodon-domain modifications.

7. Unusual noncanonical intron editing is important for tRNA splicing in Trypanosoma brucei.

8. Biochemical and genetic evidence for a role of IGHMBP2 in the translational machinery.

9. Effect of intron mutations on processing and function of Saccharomyces cerevisiae SUP53 tRNA in vitro and in vivo.

10. Nuclear pore proteins are involved in the biogenesis of functional tRNA.