Literature DB >> 6339854

Evidence that chicken hypothalamic luteinizing hormone-releasing hormone is [Gln8]-LH-RH.

K Miyamoto, Y Hasegawa, M Igarashi, N Chino, S Sakakibara, K Kangawa, H Matsuo.   

Abstract

As previously reported, chicken LH-RH has been purified in a yield of ca. 2.5 micrograms from 2,000 chicken hypothalmi, and we have estimated its chemical structure to be [Gln8]-LH-RH (1). Based on our previous observation (1), [Gln8]-LH-RH and [Glu8]-LH-RH have been synthesized by the solution method for the purpose of the structural confirmation. Synthetic [Gln8]-LH-RH was confirmed to be identical to natural chicken LH-RH on a HPLC system. For further structural confirmation, chymotryptic and thermolytic peptides from synthetic [Gln8]-LH-RH and natural chicken LH-RH were also identified. Thus, these studies support the view that chicken LH-RH has the following structure; pGlu-His-Trp-Ser-Tyr-Gly-Leu-Gln-Pro-Gly-NH2, [Gln8]-LH-RH. The gonadotropin releasing potency of synthetic [Gln8]-LH-RH was also in a good agreement with that of natural preparation.

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Year:  1983        PMID： 6339854     DOI： 10.1016/0024-3205(83)90808-1

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  9 in total

Review 1.  Gonadotropin-releasing hormone (GnRH): from fish to mammalian brains.

Authors:  Gustavo M Somoza; Leandro A Miranda; Pablo Strobl-Mazzulla; Leonardo Gastón Guilgur
Journal:  Cell Mol Neurobiol       Date:  2002-12       Impact factor: 5.046

2.  Neuroendocrine control of reproduction in lampreys.

Authors:  S A Sower
Journal:  Fish Physiol Biochem       Date:  1990-09       Impact factor: 2.794

3.  Chromatographic and immunological identification of gonadotropin-releasing hormone in five marine teleosts.

Authors:  K Okuzawa; M Amano; K Aida; Y Hasegawa; H Tanaka; H Kagawa
Journal:  Fish Physiol Biochem       Date:  1993-12       Impact factor: 2.794

Review 4.  Evolutionary aspects of gonadotropin-releasing hormone and its receptor.

Authors:  J A King; R P Millar
Journal:  Cell Mol Neurobiol       Date:  1995-02       Impact factor: 5.046

Review 5.  Neuroendocrinology of reproduction: Is gonadotropin-releasing hormone (GnRH) dispensable?

Authors:  Kathleen E Whitlock; John Postlethwait; John Ewer
Journal:  Front Neuroendocrinol       Date:  2019-02-22       Impact factor: 8.606

6.  Identification of the second gonadotropin-releasing hormone in chicken hypothalamus: evidence that gonadotropin secretion is probably controlled by two distinct gonadotropin-releasing hormones in avian species.

Authors:  K Miyamoto; Y Hasegawa; M Nomura; M Igarashi; K Kangawa; H Matsuo
Journal:  Proc Natl Acad Sci U S A       Date:  1984-06       Impact factor: 11.205

7.  A second gene for gonadotropin-releasing hormone: cDNA and expression pattern in the brain.

Authors:  S A White; C T Bond; R C Francis; T L Kasten; R D Fernald; J P Adelman
Journal:  Proc Natl Acad Sci U S A       Date:  1994-02-15       Impact factor: 11.205

8.  Localization of avian LHRH-immunoreactive neurons in the hypothalamus of the domestic fowl, Gallus domesticus, and the Japanese quail, Coturnix coturnix.

Authors:  S Mikami; S Yamada; Y Hasegawa; K Miyamoto
Journal:  Cell Tissue Res       Date:  1988-01       Impact factor: 5.249

9.  Production of monoclonal antibodies against avian LHRH-I.

Authors:  B Alston-Mills; Q C Li; M A Ottiner
Journal:  In Vitro Cell Dev Biol       Date:  1989-10
  9 in total

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