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Literature DB >> 6339567

Counterimmunoelectrophoresis in the serodiagnosis of Legionnaires' disease.

Abstract

Counterimmunoelectrophoresis (CIE) was found to be a rapid, specific method for detecting circulating antibodies to Legionella pneumophila, using a simple ultrasonically disrupted antigen. The diagnostic specificity of the technique was 93% and the diagnostic sensitivity was 86.3%. Both IgM and IgG classes of antibody can be detected. There is some cross-reactivity between serogroup 1 and serogroup 6 but none between serogroup 1 and serogroups 3, 4, and 5. It is suggested that CIE may provide a simple, reproducible screening test for Legionnaires' disease.

Entities: Disease

Mesh：

Substances：

Year: 1983 PMID： 6339567 PMCID： PMC498247 DOI： 10.1136/jcp.36.4.466

Source DB: PubMed Journal: J Clin Pathol ISSN： 0021-9746 Impact factor: 3.411

12 in total

1. The relationship between fluorescent, agglutinating, and precipitating antibodies to Candida albicans and their immunoglobulin classes.

Authors: T Lehner; H R Buckley; I G Murray
Journal: J Clin Pathol Date: 1972-04 Impact factor: 3.411

2. Immunoglobulin specificity of the microagglutination test for the Legionnaires' disease bacterium.

Authors: C E Farshy; D D Cruce; G C Klein; H W Wilkinson; J C Feeley
Journal: Ann Intern Med Date: 1979-04 Impact factor: 25.391

3. Serological differentiation of Legionnaires' Disease and Mycoplasma pneumoniae pneumonia.

Authors: A G Taylor; T G Harrison; B E Andrews; M Sillis
Journal: Lancet Date: 1980-04-05 Impact factor: 79.321

4. Four serogroups of Legionnaires' disease bacteria defined by direct immunofluorescence.

Authors: R M McKinney; L Thacker; P P Harris; K R Lewallen; G A Hebert; P H Edelstein; B M Thomason
Journal: Ann Intern Med Date: 1979-04 Impact factor: 25.391

5. The antibody response in Legionnaires' disease.

Authors: J Nagington; T G Wreghitt; J O Tobin; A D Macrae
Journal: J Hyg (Lond) Date: 1979-10

6. False positive reactions in the indirect fluorescent antibody test for Legionnaires' disease eliminated by use of formolised yolk-sac antigen.

Authors: A G Taylor; T G Harrison; M W Dighero; C M Bradstreet
Journal: Ann Intern Med Date: 1979-04 Impact factor: 25.391

7. Legionnaires' disease: antigenic peculiarities, strain differences, and antibiotic sensitivities of the agent.

Authors: R A Ormsbee; M G Peacock; G L Lattimer; L A Page; P Fiset
Journal: J Infect Dis Date: 1978-08 Impact factor: 5.226

8. A high molecular weight antigen in Legionnaires' disease bacterium: isolation and partial characterization.

Authors: W Johnson; J A Elliott; C M Helms; E D Renner
Journal: Ann Intern Med Date: 1979-04 Impact factor: 25.391

9. Relation of Mycoplasma pneumoniae seroreactivity, immunosuppression, and chronic disease to Legionnaires' disease. A twelve-month prospective study of sporadic cases in Massachusetts.

Authors: G F Grady; R F Gilfillan
Journal: Ann Intern Med Date: 1979-04 Impact factor: 25.391

10. Legionnaires' disease serology. Effect of antigen preparation on specificity and sensitivity of the indirect fluorescent antibody test.

Authors: G L Lattimer; B A Cepil
Journal: J Clin Pathol Date: 1980-06 Impact factor: 3.411

2 in total

1. Serogrouping of Legionella pneumophila by double diffusion and counter immunoelectrophoresis.

Authors: M G Holliday; J Barker
Journal: J Clin Pathol Date: 1984-11 Impact factor: 3.411

Review 2. Legionella and Legionnaires' disease: 25 years of investigation.

Authors: Barry S Fields; Robert F Benson; Richard E Besser
Journal: Clin Microbiol Rev Date: 2002-07 Impact factor: 26.132

2 in total