Literature DB >> 6339513

Induction of diphtheria toxin-resistant mutants in human cells by halogenated compounds.

A M Ferreri, P Rocchi, A Capucci, G Prodi.   

Abstract

The mutagenic power of 1,2-dichloroethane, 1,2-dibromoethane, 1,2-diiodoethane was tested in the human cell line, EUE. In our mutagenic system, based on selection against diphtheria toxin, the halogenated compounds, 1,2-dichloroethane and 1,2-dibromoethane revealed a strong mutagenic effect, whereas 1,2-diiodoethane was not mutagenic at a concentration allowing survival of 41%.

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Year:  1983        PMID： 6339513     DOI： 10.1007/bf00391843

Source DB:  PubMed          Journal:  J Cancer Res Clin Oncol        ISSN： 0171-5216            Impact factor:   4.553


  6 in total

1.  Isolation and characterization of mutants of human diploid fibroblasts resistant to diphtheria toxin.

Authors:  R S Gupta; L Siminovitch
Journal:  Proc Natl Acad Sci U S A       Date:  1978-07       Impact factor: 11.205

2.  The mutagenic effect of 1,2-dichloroethane on Salmonella typhimurium I. Activation through conjugation with glutathion in vitro.

Authors:  U Rannug; A Sundvall; C Ramel
Journal:  Chem Biol Interact       Date:  1978-01       Impact factor: 5.192

Review 3.  Validation and comparative studies on 180 chemicals with S. typhimurium strains and V79 Chinese hamster cells in the presence of various metabolizing systems.

Authors:  H Bartsch; C Malaveille; A M Camus; G Martel-Planche; G Brun; A Hautefeuille; N Sabadie; A Barbin; T Kuroki; C Drevon; C Piccoli; R Montesano
Journal:  Mutat Res       Date:  1980-07       Impact factor: 2.433

4.  Induction of diphtheria toxin-resistant mutants in human cells by ultraviolet light.

Authors:  P Rocchi; A M Ferreri; A Capucci; G Prodi
Journal:  Carcinogenesis       Date:  1981       Impact factor: 4.944

5.  The relation between the structure of vicinal dihalogen compounds and their mutagenic activation via conjugation to glutathione.

Authors:  P J van Bladeren; D D Breimer; G M Rotteveel-Smijs; P de Knijff; G R Mohn; B van Meeteren-Wälchli; W Buijs; A van der Gen
Journal:  Carcinogenesis       Date:  1981       Impact factor: 4.944

6.  Polycyclic hydrocarbons induction of diphtheria toxin-resistant mutants in human cells.

Authors:  P Rocchi; A M Ferreri; R Borgia; G Prodi
Journal:  Carcinogenesis       Date:  1980-09       Impact factor: 4.944
  6 in total
  2 in total

1.  In vitro microsome- and cytosol-mediated binding of 1,2-dichloroethane and 1,2-dibromoethane with DNA.

Authors:  A Colacci; M Mazzullo; G Arfellini; G Prodi; S Grilli
Journal:  Cell Biol Toxicol       Date:  1985-01       Impact factor: 6.691

2.  In vivo and in vitro binding of 1,2-dibromoethane and 1,2-dichloroethane to macromolecules in rat and mouse organs.

Authors:  G Arfellini; S Bartoli; A Colacci; M Mazzullo; M C Galli; G Prodi; S Grilli
Journal:  J Cancer Res Clin Oncol       Date:  1984       Impact factor: 4.553
  2 in total

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