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Literature DB >> 6339378

Peroral immunization of rats with Escherichia coli heat-labile enterotoxin delivered by microspheres.

Abstract

The antigenicity of the Escherichia coli heat-labile enterotoxin was not protected against the adverse effect of gastric acidity when the toxin was given together with bicarbonate for peroral immunization to rats, but immunization with the heat-labile enterotoxin encapsulated in pH-dependent microspheres aroused the same strong degree of serum and mucosal antitoxin responses and of protection against challenge as was achieved by peroral immunization after ablation of gastric secretions by pretreatment with cimetidine.

Entities: Chemical Disease Species

Mesh：

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Year: 1983 PMID： 6339378 PMCID： PMC348049 DOI： 10.1128/iai.39.2.1000-1003.1983

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

12 in total

1. Antigenicity of purified glutaraldehyde-treated cholera toxoid administered orally.

Authors: M M Levine; T P Hughes; C R Young; S O'Donnell; J P Craig; H P Holley; E J Bergquist
Journal: Infect Immun Date: 1978-07 Impact factor: 3.441

2. Immunity to experimental cholera. III. Enhanced duration of protection after sequential parenteral-oral administration of toxoid to dogs.

Authors: N F Pierce; R B Sack; B K Sircar
Journal: J Infect Dis Date: 1977-06 Impact factor: 5.226

3. Intestinal antibody responses after immunisation with cholera B subunit.

Authors: A M Svennerholm; D A Sack; J Holmgren; P K Bardhan
Journal: Lancet Date: 1982-02-06 Impact factor: 79.321

4. Comparative study of varying regimens to improve steatorrhoea and creatorrhoea in cystic fibrosis: Effectiveness of an enteric-coated preparation with and without antacids and cimetidine.

Authors: R Gow; R Bradbear; P Francis; R Shepherd
Journal: Lancet Date: 1981-11-14 Impact factor: 79.321

5. Influence of route of administration on immediate and extended protection in rats immunized with Escherichia coli heart-labile enterotoxin.

Authors: F A Klipstein; R F Engert
Journal: Infect Immun Date: 1980-01 Impact factor: 3.441

6. Protective effect of active immunization with purified Escherichia coli heat-labile enterotoxin in rats.

Authors: F A Klipstein; R F Engert
Journal: Infect Immun Date: 1979-03 Impact factor: 3.441

7. Isolation and characterization of homogeneous heat-labile enterotoxins with high specific activity from Escherichia coli cultures.

Authors: J D Clements; R A Finkelstein
Journal: Infect Immun Date: 1979-06 Impact factor: 3.441

8. Induction of a mucosal antitoxin response and its role in immunity to experimental canine cholera.

Authors: N F Pierce; W C Cray; B K Sircar
Journal: Infect Immun Date: 1978-07 Impact factor: 3.441

9. Arousal of mucosal secretory immunoglobulin A antitoxin in rats immunized with Escherichia coli heat-labile enterotoxin.

Authors: F A Klipstein; R F Engert; J D Clements
Journal: Infect Immun Date: 1982-09 Impact factor: 3.441

10. Protective effect of immunization of rats with holotoxin or B subunit of Escherichia coli heat-labile enterotoxin.

Authors: F A Klipstein; R F Engert
Journal: Infect Immun Date: 1981-01 Impact factor: 3.441

4 in total

1. Oral immunization with recombinant Norwalk virus-like particles induces a systemic and mucosal immune response in mice.

Authors: J M Ball; M E Hardy; R L Atmar; M E Conner; M K Estes
Journal: J Virol Date: 1998-02 Impact factor: 5.103

2. Improved bioavailability of orally administered andrographolide from pH-sensitive nanoparticles.

Authors: Bothiraja Chellampillai; Atmaram Pandurang Pawar
Journal: Eur J Drug Metab Pharmacokinet Date: 2010-12-30 Impact factor: 2.441

3. Effects of Clostridium difficile toxins given intragastrically to animals.

Authors: D M Lyerly; K E Saum; D K MacDonald; T D Wilkins
Journal: Infect Immun Date: 1985-02 Impact factor: 3.441

4. Protection in rabbits immunized with a vaccine of Escherichia coli heat-stable toxin cross-linked to the heat-labile toxin B subunit.

Authors: F A Klipstein; R F Engert; R A Houghten
Journal: Infect Immun Date: 1983-06 Impact factor: 3.441

4 in total