Failure of the commercial human IgG immunoglobulin preparation Polyglobin to enhance combined phagocytic and serum bactericidal activity of normal blood against Serratia marcescens.

The IgG immunoglobulin preparation Polyglobin failed to enhance the combined phagocytic and serum bactericidal activity of 65 vol% of fresh defibrinated human blood from health adults against representative test strains of Serratia marcescens, despite documented O-agglutinin activity of Polyglobin against every test strain employed. It was concluded that pooled human IgG immunoglobulin, i.e. 'natural' IgG antibodies, would not be expected to exert a beneficial effect against S. marcescens in patients with sufficient residual, functional 'natural' antibodies and complement.