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Literature DB >> 6338334

Betaine, metabolic by-product or vital methylating agent?

Abstract

The possible physiological role of betaine, the oxidative product of choline, is considered. It is proposed that betaine, instead of merely being a metabolic by-product of choline oxidation, may serve as an important methylating agent when normal methylating pathways are impaired by ethanol ingestion, drugs or nutritional imbalances. Furthermore, betaine may prove to have therapeutic application in cases of altered folate, vitamin B12 or methionine metabolism.

Entities: Chemical

Mesh：

Substances：

Year: 1983 PMID： 6338334 DOI： 10.1016/0024-3205(83)90311-9

Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037

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Cited

10 in total

1. An internal reaction chamber in dimethylglycine oxidase provides efficient protection from exposure to toxic formaldehyde.

Authors: Tewes Tralau; Pierre Lafite; Colin Levy; John P Combe; Nigel S Scrutton; David Leys
Journal: J Biol Chem Date: 2009-04-15 Impact factor: 5.157

Review 2. Choline and betaine in health and disease.

Authors: Per Magne Ueland
Journal: J Inherit Metab Dis Date: 2010-05-06 Impact factor: 4.982

3. Regulation of phosphatidylcholine and phosphatidylethanolamine synthesis in rat hepatocytes by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR).

Authors: Martin Houweling; Wil Klein; Math J H Geelen
Journal: Biochem J Date: 2002-02-15 Impact factor: 3.857

10. Parturition and postpartum dietary change altered ruminal pH and the predicted functions of rumen bacterial communities but did not alter the bacterial composition in Holstein cows.

Authors: Yo-Han Kim; Atsushi Kimura; Toshihisa Sugino; Shigeru Sato
Journal: Front Vet Sci Date: 2022-08-26

10 in total

Betaine, metabolic by-product or vital methylating agent?

1. An internal reaction chamber in dimethylglycine oxidase provides efficient protection from exposure to toxic formaldehyde.

Review 2. Choline and betaine in health and disease.

3. Regulation of phosphatidylcholine and phosphatidylethanolamine synthesis in rat hepatocytes by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR).

Review 4. In vivo magnetic resonance spectroscopy of liver tumors and metastases.

5. Betaine prevents ethanol-induced oxidative stress and reduces total homocysteine in the rat cerebellum.

Review 6. Homocysteine Metabolism in Pregnancy and Developmental Impacts.

7. Modulation of phosphatidylcholine biosynthesis by peroxisome proliferating fatty acid analogues.

8. Pathway of glycine betaine biosynthesis in Aspergillus fumigatus.

9. Organic and Peptidyl Constituents of Snake Venoms: The Picture Is Vastly More Complex Than We Imagined.

10. Parturition and postpartum dietary change altered ruminal pH and the predicted functions of rumen bacterial communities but did not alter the bacterial composition in Holstein cows.