| Literature DB >> 6337964 |
M Hirashima, Y Hirotsu, T Yoshimura, H Hayashi.
Abstract
In complement-depleted condition induced by cobra venom factor (CoF), tissue macrophage reaction and macrophage chemotactic activity (MCA) in skin extract from skin lesions induced by DNP-Ascaris extract (DNP-As) were decreased, respectively. MCA in the fraction containing macrophage chemotactic factor b (B fraction) was decreased completely. While MCA in the fraction containing macrophage chemotactic factor a and c (A fraction) was affected only slightly. These results suggested that the decrease of MCA of B-fraction might be associated with depletion of complement system by CoF. Using anti-C5 antibody, it was confirmed that macrophage chemotactic factor-b (MCF-b) (MW 14,000: thermostable) might be derived from C5 fragment in vivo.Entities:
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Year: 1983 PMID： 6337964 DOI： 10.1159/000233348
Source DB: PubMed Journal: Int Arch Allergy Appl Immunol ISSN： 0020-5915