Literature DB >> 6337614

The dose-response for x-ray induction of myeloid leukaemia in male CBA/H mice.

R H Mole, D G Papworth, M J Corp.   

Abstract

The form of the dose-response for induction of malignant diseases in vivo by ionizing radiation is not yet established in spite of its scientific interest and its practical importance. Considerably extended observations have confirmed that the dose-response for acute myeloid leukaemia induced in male CBA/H mice by X-ray exposure is highly curvilinear. The dose-response was well fitted by the expression aD2e-lambda D (D = dose) in agreement with induction at the cellular level in proportion to D2 over the whole dose range 0.25-6.0 Gy. The factor e-lambda D accounts for the inescapable concomitant inactivating action of the inducing irradiation. The quantitative aspects of induction of myeloid leukaemia by ionizing radiation are unlike the induction of genetic mutation or cell inactivation and suggest that interaction of two adjoining cells is an essential element in radiation leukaemogenesis.

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Year:  1983        PMID： 6337614      PMCID： PMC2011291          DOI： 10.1038/bjc.1983.37

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  8 in total

1.  Whole body x-irradiation of experimental animals; a short summary of the methods used at the M.R.C. Radiobiological Research Unit, A.E.R.E., Harwell, between 1949-1956.

Authors:  M J CORP
Journal:  Phys Med Biol       Date:  1957-04       Impact factor: 3.609

2.  Myeloid leukaemia in x-ray irradiated CBA mice.

Authors:  I R Major; R H Mole
Journal:  Nature       Date:  1978-03-30       Impact factor: 49.962

3.  Late effects of fast neutrons and gamma-rays in mice as influenced by the dose rate of irradiation: induction of neoplasia.

Authors:  A C Upton; M L Randolph; J W Conklin; M A Kastenbaum; M Slater; G S Melville; F P Conte; J A Sproul
Journal:  Radiat Res       Date:  1970-03       Impact factor: 2.841

4.  The shape of the dose-response curve for radiation carcinogenesis. Extrapolation to low doses.

Authors:  J M Brown
Journal:  Radiat Res       Date:  1977-07       Impact factor: 2.841

5.  In vitro radiosensitivity of six human cell lines: a comparative study with different statistical models.

Authors:  B Fertil; P J Deschavanne; B Lachet; E P Malaise
Journal:  Radiat Res       Date:  1980-05       Impact factor: 2.841

6.  RBE for carcinogenesis by fission neutrons.

Authors:  R H Mole
Journal:  Health Phys       Date:  1979-03       Impact factor: 1.316

7.  Carcinogenesis by thorotrast and other sources of irradiation, especially other alpha-emitters.

Authors:  R H Mole
Journal:  Environ Res       Date:  1979-02       Impact factor: 6.498

8.  Ionizing radiation as a carcinogen: practical questions and academic pursuits The Silvanus Thompson Memorial Lecture delivered at The British Institute of Radiology on April 18, 1974.

Authors:  R H Mole
Journal:  Br J Radiol       Date:  1975-03       Impact factor: 3.039
  8 in total
  15 in total

1.  Reduced PU.1 expression causes myeloid progenitor expansion and increased leukemia penetrance in mice expressing PML-RARalpha.

Authors:  Matthew J Walter; John S Park; Rhonda E Ries; Steven K M Lau; Michael McLellan; Sara Jaeger; Richard K Wilson; Elaine R Mardis; Timothy J Ley
Journal:  Proc Natl Acad Sci U S A       Date:  2005-08-19       Impact factor: 11.205

Review 2.  Radiation and cancer: a two-edged sword.

Authors:  G E Adams
Journal:  Br J Cancer Suppl       Date:  1987-06

3.  A two-mutation model of radiation-induced acute myeloid leukemia using historical mouse data.

Authors:  Fieke Dekkers; Harmen Bijwaard; Simon Bouffler; Michele Ellender; René Huiskamp; Christine Kowalczuk; Emmy Meijne; Marjolein Sutmuller
Journal:  Radiat Environ Biophys       Date:  2010-09-15       Impact factor: 1.925

4.  Neutron Radiobiology and Dosimetry.

Authors:  Daniela L Stricklin; Jama VanHorne-Sealy; Carmen I Rios; Lisa A Scott Carnell; Lanyn P Taliaferro
Journal:  Radiat Res       Date:  2021-05-01       Impact factor: 2.841

5.  Curvilinearity in the dose-response curve for cancer in Japanese atomic bomb survivors.

Authors:  M P Little; C R Muirhead
Journal:  Environ Health Perspect       Date:  1997-12       Impact factor: 9.031

6.  Expression profiling of murine acute promyelocytic leukemia cells reveals multiple model-dependent progression signatures.

Authors:  Matthew J Walter; John S Park; Steven K M Lau; Xia Li; Andrew A Lane; Rakesh Nagarajan; William D Shannon; Timothy J Ley
Journal:  Mol Cell Biol       Date:  2004-12       Impact factor: 4.272

7.  Irradiation Enhances Abscopal Anti-tumor Effects of Antigen-Specific Immunotherapy through Regulating Tumor Microenvironment.

Authors:  Ming-Cheng Chang; Yu-Li Chen; Han-Wei Lin; Ying-Cheng Chiang; Chi-Fang Chang; Shu-Feng Hsieh; Chi-An Chen; Wei-Zen Sun; Wen-Fang Cheng
Journal:  Mol Ther       Date:  2017-11-21       Impact factor: 11.454

8.  Effects of 28Si ions, 56Fe ions, and protons on the induction of murine acute myeloid leukemia and hepatocellular carcinoma.

Authors:  Michael M Weil; F Andrew Ray; Paula C Genik; Yongjia Yu; Maureen McCarthy; Christina M Fallgren; Robert L Ullrich
Journal:  PLoS One       Date:  2014-08-15       Impact factor: 3.240

9.  Implication of replicative stress-related stem cell ageing in radiation-induced murine leukaemia.

Authors:  N Ban; M Kai
Journal:  Br J Cancer       Date:  2009-06-09       Impact factor: 7.640

10.  Atomic Bomb Survivors Life-Span Study: Insufficient Statistical Power to Select Radiation Carcinogenesis Model.

Authors:  Yehoshua Socol; Ludwik Dobrzyński
Journal:  Dose Response       Date:  2015-05-04       Impact factor: 2.658
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