| Literature DB >> 6336155 |
W Biddle, C M Ambrus, H Gastpar, J L Ambrus.
Abstract
The xanthine derivative, Trental (pentoxifylline) was found to inhibit several human leukemic and lymphoma cell lines in tissue cultures. Optimal concentrations were less inhibitory for a normal B-lymphocyte cell line then for the neoplastic cell lines. In fact, small concentrations stimulated DNA synthesis in the normal cell line. Trental and beta-interferon appeared to be additive synergists at certain dosages. Possible mechanisms are discussed.Entities:
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Year: 1984 PMID： 6336155
Source DB: PubMed Journal: J Med ISSN： 0025-7850