Literature DB >> 6335993

Changes in lysosomal enzyme activities of eye tissues in endotoxin-induced inflammation.

P K Tsung, J Price, F J Holly.   

Abstract

Lysosomal enzyme activities in rabbit ocular tissues were examined at various times after the intravitreal injection of endotoxin. Lysosomal enzyme activities in the aqueous, vitreous, and pigment epithelium-choroid were elevated 3 h after injection. It is deduced from the fluorescein-labeled dextran and SDS-polyacrylamide gel electrophoresis analysis of the aqueous, vitreous, and pigment epithelium-choroid from endotoxin injected rabbits that the elevation of lysosomal enzyme activities are probably due to a breakdown in blood-ocular barriers.

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Year:  1983        PMID： 6335993     DOI： 10.1007/bf00917263

Source DB:  PubMed          Journal:  Inflammation        ISSN： 0360-3997            Impact factor:   4.092


  10 in total

1.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

2.  The effects of experimental uveitis on anterior uveal prostaglandin transport and aqueous humor composition.

Authors:  L Z Bito
Journal:  Invest Ophthalmol       Date:  1974-12

3.  Possible heterogeneity of the distribution of lysosomal marker enzymes among "lysosomal particles" of rat liver.

Authors:  M Futai; P K Tsung; D Mizuno
Journal:  Biochim Biophys Acta       Date:  1971-02-28

4.  Ocular vascular permeability. Effect of systemic administration of bacterial endotoxin.

Authors:  E L Howes; S B Aronson; D G McKay
Journal:  Arch Ophthalmol       Date:  1970-09

5.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

6.  Protease activities in human tears.

Authors:  P K Tsung; F J Holly
Journal:  Curr Eye Res       Date:  1981       Impact factor: 2.424

Review 7.  The role of lysosomes in immune responses.

Authors:  G Weissmann; P Dukor
Journal:  Adv Immunol       Date:  1970       Impact factor: 3.543

8.  Protein kinase and phosphatases from human polymorphonuclear leucoytes.

Authors:  P K Tsung; T Sakamoto; G Weissmann
Journal:  Biochem J       Date:  1975-03       Impact factor: 3.857

9.  Release of prostaglandin-like substances by Shigella endotoxin and its inhibition by non-steroidal anti-inflammatory compounds.

Authors:  P Bhattacherjee
Journal:  Br J Pharmacol       Date:  1975-08       Impact factor: 8.739

10.  Studies on lysosomes. I. The effects of endotoxin, endotoxin tolerance, and cortisone on the release of acid hydrolases from a granular fraction of rabbit liver.

Authors:  G WEISSMANN; L THOMAS
Journal:  J Exp Med       Date:  1962-10-01       Impact factor: 14.307
  10 in total
  2 in total

1.  Ultrastructural localization of a lysosomal enzyme in resin-embedded lymphocytes.

Authors:  G Bou-Gharios; J Moss; I Olsen; T Partridge
Journal:  Histochemistry       Date:  1988

2.  The shape and distribution of lysosomes and endocytosis in the ciliary epithelial cells of rats.

Authors:  N Araki; T I Tenkova; T Fujiwara; Y Takashima
Journal:  Cell Tissue Res       Date:  1993-10       Impact factor: 5.249
  2 in total

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