Literature DB >> 6335261

Calcitonin gene-related peptide acts within the central nervous system to inhibit gastric acid secretion.

H J Lenz, M T Mortrud, W W Vale, J E Rivier, M R Brown.   

Abstract

The central nervous system effect of calcitonin gene-related peptide (CGRP) on gastric acid secretion was studied in conscious freely moving rats. CGRP (220 fmol to 2.2 nmol) injected into the lateral cerebral ventricle or intravenously inhibited gastric acid secretion. Intravenous passive immunization with CGRP antiserum prevented the inhibitory effect of CGRP following intravenous but not intracerebroventricular administration. Adrenalectomy and noradrenergic blockade with bretylium tosylate did not significantly alter the inhibitory action of CGRP given intracerebroventricularly on gastric secretion. These studies indicate that CGRP acts within the central nervous system to potently decrease gastric acid secretion by mechanism(s) not dependent on intact sympathetic nervous function.

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Year:  1984        PMID： 6335261     DOI： 10.1016/0167-0115(84)90079-x

Source DB:  PubMed          Journal:  Regul Pept        ISSN： 0167-0115


  4 in total

1.  Quadruple colocalization of calretinin, calcitonin gene-related peptide, vasoactive intestinal peptide, and substance P in fibers within the villi of the rat intestine.

Authors:  K R Isaacs; L Winsky; K I Strauss; D M Jacobowitz
Journal:  Cell Tissue Res       Date:  1995-06       Impact factor: 5.249

2.  Central cardiovascular effects of calcitonin gene-related peptide: interaction with noradrenaline in the nucleus tractus solitarius of rats.

Authors:  M Vallejo; S Lightman; I Marshall
Journal:  Exp Brain Res       Date:  1988       Impact factor: 1.972

3.  Cerebroventricular calcitonin gene-related peptide inhibits rat duodenal bicarbonate secretion by release of norepinephrine and vasopressin.

Authors:  H J Lenz; M R Brown
Journal:  J Clin Invest       Date:  1990-01       Impact factor: 14.808

4.  Intracerebroventricular administration of human calcitonin and human calcitonin gene-related peptide inhibits meal-stimulated gastric acid secretion in the dog.

Authors:  H J Lenz; M R Brown
Journal:  Dig Dis Sci       Date:  1987-04       Impact factor: 3.199
  4 in total

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