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Literature DB >> 6335134

Selection of resistant mutants of Citrobacter freundii by second and third-generation cephalosporins and imipenem.

A M del Rosario Valencia, A Vuye, J Pijck.

Abstract

Using a single-step selection procedure, resistant mutants could be obtained from three clinical isolates of Citrobacter freundii with two second-generation and four third-generation cephalosporins but not with imipenem. All mutants showed a drastically increased beta-lactamase activity and were cross-resistant to all the cephalosporins examined. Combinations of cloxacillin with the cephalosporins were markedly synergistic, suggesting the principal role of the cephalosporinase in the resistance of these mutants.

Entities: Chemical Species

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Year: 1984 PMID： 6335134 DOI： 10.1007/bf01645225

Source DB: PubMed Journal: Infection ISSN： 0300-8126 Impact factor: 3.553

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References

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Selection of resistant mutants of Citrobacter freundii by second and third-generation cephalosporins and imipenem.

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