Literature DB >> 6334548

Studies with a human plasma-derived immunosuppressive, anti-lymphoma factor.

J L Farmer, M D Prager.   

Abstract

A low-molecular-weight (1,400) factor isolated from a human plasma alpha-globulin concentrate by acid-salt dissociation and ultrafiltration inhibits proliferation of mitogen-stimulated T cells and L1210 leukemia cells. The factor (UM05R) inhibits DNA, RNA, and protein synthesis in sensitive cells, acts in G1 of the cell cycle, and appears to suppress mitogen-responsive T cells without an accessory cell requirement. UM05R activity is enhanced by known cAMP-elevating agents and by sulfhydryl compounds. The results of the present study are consistent with the hypothesis that the plasma-derived agent inhibits lympho-proliferation as a result of elevation of intracellular cAMP.

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Year:  1984        PMID： 6334548     DOI： 10.1007/bf00205742

Source DB:  PubMed          Journal:  Cancer Immunol Immunother        ISSN： 0340-7004            Impact factor:   6.968


  20 in total

1.  Serum-derived immunosuppressive substances. I. Partial purification and range of action.

Authors:  F Miller
Journal:  Transplantation       Date:  1976-03       Impact factor: 4.939

2.  Isolation of an immunosuppressive peptide fraction from human plasma.

Authors:  J C Occhino; A H Glasgow; S R Cooperband; J A Mannick; K Schmid
Journal:  J Immunol       Date:  1973-03       Impact factor: 5.422

3.  Regulatory substances produced by lymphocytes--VII. IDS (inhibitor of DNA synthesis) inhibits stimulated lymphocyte proliferation by activation of membrane adenylate cyclase at a restriction point in late G1.

Authors:  B V Jegasothy; Y Namba; B H Waksman
Journal:  Immunochemistry       Date:  1978-08

4.  Inhibition of T- and B-lymphocyte functions by normal immunosuppressive protein.

Authors:  N Hanna; R Kalderon; D Nelken
Journal:  Immunology       Date:  1975-09       Impact factor: 7.397

5.  The relationship between direct migration inhibition with measles antigen and E rosettes in normals and patients with multiple sclerosis.

Authors:  V Utermohlen; J Farmer; J Kornbluth; M Kornstein
Journal:  Clin Immunol Immunopathol       Date:  1978-01

6.  Function of 2-mercaptoethanol as a macrophage substitute in the primary immune response in vitro.

Authors:  H Lemke; H G Opitz
Journal:  J Immunol       Date:  1976-08       Impact factor: 5.422

7.  Defective recognitive immunity in family aggregates of colon carcinoma.

Authors:  N T Berlinger; C Lopez; M Lipkin; J E Vogel; R A Good
Journal:  J Clin Invest       Date:  1977-05       Impact factor: 14.808

8.  Association of sepsis with an immunosuppressive polypeptide in the serum of burn patients.

Authors:  M B Constantian
Journal:  Ann Surg       Date:  1978-08       Impact factor: 12.969

9.  In vitro induction of polyclonal killer T cells with 2-mercaptoethanol and the essential role of macrophages in this process.

Authors:  T Igarashi; M Okada; T Kishimoto; Y Yamamura
Journal:  J Immunol       Date:  1977-05       Impact factor: 5.422

10.  Interaction of cholera toxin and toxin derivatives with lymphocytes. I. Binding properties and interference with lectin-induced cellular stimulation.

Authors:  J Holmgren; L Lindholm; I Lönnroth
Journal:  J Exp Med       Date:  1974-04-01       Impact factor: 14.307
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