Electronystagmographic findings in long-term low-dose quinine ingestion. A preliminary report.

Seventeen subjects were used in this study to measure the long-term effects of low-dose quinine ingestion as correlated with electronystagmographic (ENG) findings in humans. Four subjects served as controls, nine subjects (low-dose group) drank 52.5 mg of quinine per day, and four subjects (high-dose group) drank 105 mg of quinine per day in commercially prepared tonic water. Only the high-dose group showed transient positional testing abnormalities on ENG. In our experiment, the high-dose group ingested one third of the recommended Food and Drug Administration adult daily oral dose of quinine.