Literature DB >> 6333878

Tiaprofenic acid overdose.

C Köppel, A Wagemann, J Tenczer, H Muth.   

Abstract

After ingestion of 2000 mg tiaprofenic acid (Surgam), a 14-year-old girl was admitted to the clinic. The ingested dose was tolerated without signs of systemic intoxication. Tiaprofenic acid, its metabolites, and products of chemical decomposition were identified by gas chromatography/mass spectrometry in the urine sample of the patient. Additionally, a previously unknown decomposition product of a metabolite was detected. For quantitation of the drug in plasma, a rapid and sensitive high-performance liquid chromatography assay was established.

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Year:  1984        PMID： 6333878

Source DB:  PubMed          Journal:  Arzneimittelforschung        ISSN： 0004-4172


  5 in total

1.  Scope and limitations of a general unknown screening by gas chromatography-mass spectrometry in acute poisoning.

Authors:  C Köppel; J Tenczer
Journal:  J Am Soc Mass Spectrom       Date:  1995-11       Impact factor: 3.109

Review 2.  Toxic effects of nonsteroidal anti-inflammatory drugs in overdose. An overview of recent evidence on clinical effects and dose-response relationships.

Authors:  S C Smolinske; A H Hall; S A Vandenberg; D G Spoerke; P V McBride
Journal:  Drug Saf       Date:  1990 Jul-Aug       Impact factor: 5.606

Review 3.  Clinical pharmacokinetics of tiaprofenic acid and its enantiomers.

Authors:  N M Davies
Journal:  Clin Pharmacokinet       Date:  1996-11       Impact factor: 6.447

Review 4.  Acute poisoning due to non-steroidal anti-inflammatory drugs. Clinical features and management.

Authors:  J A Vale; T J Meredith
Journal:  Med Toxicol       Date:  1986 Jan-Feb

Review 5.  Non-narcotic analgesics. Problems of overdosage.

Authors:  T J Meredith; J A Vale
Journal:  Drugs       Date:  1986       Impact factor: 9.546
  5 in total

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