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Literature DB >> 6333380

Telomeric association of chromosomes in B-cell lymphoid leukemia.

Abstract

About 20% of leukemic bone marrow cells from each of two patients with B-cell lymphoid leukemias showed apparent translocations which appeared to be the result of telomeric association. In one patient, whole chromosomes were associated telomere to telomere in pairs; in the other patient, telomeres of whole chromosomes were associated with breakpoints located close to the proximal or distal ends of the heterochromatic band 1q12. Repeated base sequences, particularly (CA)n sequences, are believed to be the basis of telomere pairing, and likewise repeated base sequences of heterochromatin may explain the association of 1qh and telomeres. Telomeric association may be considered as a potential origin of new stable cytogenetic combinations that have a role in oncogene transposition and tumor etiology.

Entities: Disease Species

Mesh：

Substances：
Heterochromatin

Year: 1984 PMID： 6333380 DOI： 10.1007/bf00291396

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

38 in total

Review 1. The possibility of latent centromeres and a proposed nomenclature system for total chromosome and whole arm translocations.

Authors: T C Hsu; S Pathak; T R Chen
Journal: Cytogenet Cell Genet Date: 1975

Telomeric association of chromosomes in B-cell lymphoid leukemia.

Review 1. The possibility of latent centromeres and a proposed nomenclature system for total chromosome and whole arm translocations.

2. NON-RANDOM CHROMOSOMAL ABERRATIONS IN SV 40-TRANSFORMED HUMAN CELLS.

3. [Comparison of the structure of chromatids of Homo sapiens and Pan troglodytes (author's transl)].

4. Compositional heterogeneity of human heterochromatin.

5. Repeated sequences in human DNA.

6. Cloning chromosome ends.

7. Human oncogene locations and chromosome aberrations.

8. Direct versus cultured preparation of bone marrow cells from 22 patients with acute myeloid leukemia.

9. Spontaneous cytogenetic abnormalities in lymphocytes from thirteen patients with ataxia telangiectasia.

10. The chromosomal basis of human neoplasia.

1. Telomere association of chromosomes induced by aphidicolin in a normal individual.

2. Subpopulations of colon cancer cells survive freezing.

3. Giant cell tumor of soft tissue is genetically distinct from its bone counterpart.

4. Origin of human chromosome 2: an ancestral telomere-telomere fusion.

5. Cytogenetic abnormalities in a rare case of giant cell osteogenic sarcoma.

6. Telomeric Associations.

7. Telomeric association in a malignant fibrous histiocytoma.

8. Dicentric chromosomes and the inactivation of the centromere.

9. Cytogenetic studies on three pheochromocytomas derived from patients with von Hippel-Lindau syndrome.

10. Recombination and its roles in DNA repair, cellular immortalization and cancer.