Literature DB >> 6333037

Behavioral effects of morphine, levorphanol, dextrorphan and naloxone in the frog Rana pipiens.

P D Pezalla, C W Stevens.   

Abstract

Systemic morphine induces explosive motor behavior and generalized muscular rigidity in frogs. Naloxone does not reverse either of these effects of morphine but at high doses causes muscular flaccidity and unresponsiveness to stimulation. Intraspinal morphine induces rigidity, but not explosive motor behavior, and this action is blocked by naloxone. Behavioral effects are seen rarely after intraspinal levorphanol (rigidity) and never after intraspinal dextrorphan or naloxone. In contrast to systemic morphine and naloxone, systemic levorphanol and dextrorphan are lethal to frogs at high doses.

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Year:  1984        PMID： 6333037     DOI： 10.1016/0091-3057(84)90217-x

Source DB:  PubMed          Journal:  Pharmacol Biochem Behav        ISSN： 0091-3057            Impact factor:   3.533


  8 in total

1.  Testing and comparison of non-opioid analgesics in amphibians.

Authors:  C W Stevens; D N MacIver; L C Newman
Journal:  Contemp Top Lab Anim Sci       Date:  2001-07

2.  Supraspinal administration of opioids with selectivity for mu-, delta- and kappa-opioid receptors produces analgesia in amphibians.

Authors:  C W Stevens; K S Rothe
Journal:  Eur J Pharmacol       Date:  1997-07-16       Impact factor: 4.432

3.  Analgesic effects of meloxicam, morphine sulfate, flunixin meglumine, and xylazine hydrochloride in African-clawed frogs (Xenopus laevis).

Authors:  Dondrae J Coble; Douglas K Taylor; Deborah M Mook
Journal:  J Am Assoc Lab Anim Sci       Date:  2011-05       Impact factor: 1.232

4.  Xendorphin B1, a novel opioid-like peptide determined from a Xenopus laevis brain cDNA library, produces opioid antinociception after spinal administration in amphibians.

Authors:  Craig W Stevens; Géza Tóth; Anna Borsodi; Sándor Benyhe
Journal:  Brain Res Bull       Date:  2007-01-04       Impact factor: 4.077

5.  Analgesic Efficacy of Tramadol and Morphine in White's Tree Frogs (Litoria caerulea).

Authors:  Jennifer C Hausmann; Ashley R Krisp; Christoph Mans; Stephen M Johnson; Kurt K Sladky
Journal:  J Am Assoc Lab Anim Sci       Date:  2021-11-09       Impact factor: 1.232

6.  Comparison of buprenorphine and butorphanol analgesia in the eastern red-spotted newt (Notophthalmus viridescens).

Authors:  Craig A Koeller
Journal:  J Am Assoc Lab Anim Sci       Date:  2009-03       Impact factor: 1.232

Review 7.  Opioid research in amphibians: an alternative pain model yielding insights on the evolution of opioid receptors.

Authors:  Craig W Stevens
Journal:  Brain Res Brain Res Rev       Date:  2004-10

Review 8.  The evolution of vertebrate opioid receptors.

Authors:  Craig W Stevens
Journal:  Front Biosci (Landmark Ed)       Date:  2009-01-01
  8 in total

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