| Literature DB >> 6332841 |
S L Hauser, H L Weiner, A K Bhan, M E Shapiro, M Che, W R Aldrich, N L Letvin.
Abstract
Adult SJL/J mice were depleted of T lymphocytes and were reconstituted with Lyt-1, Lyt-2, or Lyt-1 + Lyt-2 cells. After immunization with MSCH, severe acute EAE developed in the Lyt-1- and the Lyt-1 + Lyt-2-reconstituted mice. Only 25% of the Lyt-2-reconstituted mice developed signs of EAE, and in those EAE onset was delayed. Thus, Lyt-1 cells mediate EAE in the mouse.Entities:
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Year: 1984 PMID： 6332841
Source DB: PubMed Journal: J Immunol ISSN： 0022-1767 Impact factor: 5.422