Literature DB >> 6332752

Genetic polymorphism of the fourth component of complement and type 1 (insulin-dependent) diabetes.

A Marcelli-Barge, J C Poirier, M Schmid, I Deschamps, H Lestradet, P Prevost, J Hors.   

Abstract

The complement proteins, Bf, C2, C4A and C4B, are closely linked to HLA. In 74 propositi and their families, and 97 controls genotyped for HLA-A, -B, -C, DR, -Bf, a high incidence of the C4BQ0 variant was detected in the patient group (33% versus 12%, p less than 0.00001); C4BQ0 was more frequent in propositi than in non-affected siblings (40 out of 74 versus 36 out of 92, p less than 0.05). When comparing the distribution of the phenotype C4BQ0 in Type 1 diabetic patients and normal control subjects, the difference was significant in patients bearing DR3 or DR4 (56% and 25%, respectively, p less than 0.003). The main linkage disequilibria were observed among the 74 propositi: B18, BfF1, C4, A3, BQ0, DR3; B12, BfS, C4, A3, BQ0, DR4. The existence of a silent allele at the C4 B locus is known to be associated with a defective immune response.

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Year:  1984        PMID： 6332752     DOI： 10.1007/bf00275664

Source DB:  PubMed          Journal:  Diabetologia        ISSN： 0012-186X            Impact factor:   10.122


  11 in total

1.  Properdin factor B alleles as markers for insulin-dependent diabetes.

Authors:  I Deschamps; H Lestradet; A Marcelli-Barge; A Benajam; M Busson; J Hors; J Dausset
Journal:  Lancet       Date:  1979-10-13       Impact factor: 79.321

2.  HLA and DRW antigens in insulin-dependent diabetes.

Authors:  P de Moerloose; M Jeannet; C Bally; C Raffoux; J P Pointel; P Sizonenko
Journal:  Br Med J       Date:  1978-04-01

3.  Statement on the nomenclature of human C4 allotypes.

Authors:  G Mauff; C A Alper; Z Awdeh; J R Batchelor; J Bertrams; G Bruun-Petersen; R L Dawkins; P Démant; J Edwards; H Grosse-Wilde; G Hauptmann; P Klouda; L Lamm; E Mollenhauer; C Nerl; B Olaisen; G O'Neill; C Rittner; M H Roos; V Skanes; P Teisberg; L Wells
Journal:  Immunobiology       Date:  1983-03       Impact factor: 3.144

4.  A new one-step method for the functional assay of the fourth component (C4) of human and guinea pig complement.

Authors:  T A Gaither; D W Alling; M M Frank
Journal:  J Immunol       Date:  1974-08       Impact factor: 5.422

5.  HLA-DR specificities among black Americans with juvenile-onset diabetes.

Authors:  G E Rodey; N White; T E Frazer; R J Duquesnoy; J V Santiago
Journal:  N Engl J Med       Date:  1979-10-11       Impact factor: 91.245

6.  HLA-A, B, C, DR antigens, Bf, C4 and glyoxalase I (GLO) polymorphisms in French Basques with insulin-dependent diabetes mellitus (IDDM).

Authors:  A Cambon-de Mouzon; E Ohayon; G Hauptmann; A Sevin; M Abbal; E Sommer; H Vergnes; J Ducos
Journal:  Tissue Antigens       Date:  1982-05

7.  HLA and complement allotypes in Type 1 (insulin-dependent) diabetes.

Authors:  J McCluskey; V J McCann; P H Kay; P J Zilko; F T Christiansen; G J O'Neill; R L Dawkins
Journal:  Diabetologia       Date:  1983-03       Impact factor: 10.122

8.  HLA genotype studies in juvenile insulin-dependent diabetes.

Authors:  I Deschamps; H Lestradet; C Bonaïti; M Schmid; M Busson; A Benajam; A Marcelli-Barge; J Hors
Journal:  Diabetologia       Date:  1980-09       Impact factor: 10.122

9.  Inherited structural polymorphism of the fourth component of human complement.

Authors:  Z L Awdeh; C A Alper
Journal:  Proc Natl Acad Sci U S A       Date:  1980-06       Impact factor: 11.205

10.  Genetic polymorphism in human glycine-rich beta-glycoprotein.

Authors:  C A Alper; T Boenisch; L Watson
Journal:  J Exp Med       Date:  1972-01       Impact factor: 14.307
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  6 in total

1.  Two distinct HLA-DR3 haplotypes are associated with age related heterogeneity in type 1 (insulin-dependent) diabetes.

Authors:  I Deschamps; A Marcelli-Barge; J C Poirier; O Cohen-Haguenauer; H Abderrahim; D Cohen; H Lestradet; J Hors
Journal:  Diabetologia       Date:  1988-12       Impact factor: 10.122

2.  Excess of maternal HLA-DR3 antigens in HLA DR3,4 positive type 1 (insulin-dependent) diabetic patients.

Authors:  I Deschamps; J Hors; F Clerget-Darpoux; E Gardais; J J Robert; A Marcelli-Berge; H Lestradet; J Dausset
Journal:  Diabetologia       Date:  1990-07       Impact factor: 10.122

3.  Complement C4 and heat shock protein 70 (HSP70) genotypes and type I diabetes mellitus.

Authors:  N J Caplen; A Patel; A Millward; R D Campbell; S Ratanachaiyavong; F S Wong; A G Demaine
Journal:  Immunogenetics       Date:  1990       Impact factor: 2.846

4.  A marked drop in the incidence of the null allele of the B gene of the fourth component of complement (C4B*Q0) in elderly subjects: C4B*Q0 as a probable negative selection factor for survival.

Authors:  J Kramer; T Fülöp; K Rajczy; A T Nguyen; G Füst
Journal:  Hum Genet       Date:  1991-04       Impact factor: 4.132

5.  Life table analysis of the risk of type 1 (insulin-dependent) diabetes mellitus in siblings according to islet cell antibodies and HLA markers. An 8-year prospective study.

Authors:  I Deschamps; C Boitard; J Hors; M Busson; A Marcelli-Barge; A Mogenet; J J Robert
Journal:  Diabetologia       Date:  1992-10       Impact factor: 10.122

6.  HLA-DR3 and -DR4 control T-lymphocyte responses to mumps and Coxsackie B4 virus: studies on patients with type 1 (insulin-dependent) diabetes and healthy subjects.

Authors:  O Bruserud; J Jervell; E Thorsby
Journal:  Diabetologia       Date:  1985-07       Impact factor: 10.122
  6 in total

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