Literature DB >> 6331625

Synthesis and catabolism of PGE2 by a nephroblastoma associated with hypercalcemia without bone metastases.

L Calò, S Cantaro, L Bertazzo, A Vianello, L Vido, A Borsatti.   

Abstract

PGE2 overproduction by a nephroblastoma associated with hypercalcemia was clearly demonstrated in a 2-month-old girl. Compared with normal tissue, tumor showed greater phospholipase A2 and PGE2 synthetase activities but metabolized PGE2 at a faster rate. Of the enzymes involved in PGE2 synthesis, those which transform arachidonic acid into PGE2 seem to be more active.

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Year:  1984        PMID: 6331625     DOI: 10.1002/1097-0142(1984)54:4<635::aid-cncr2820540408>3.0.co;2-m

Source DB:  PubMed          Journal:  Cancer        ISSN: 0008-543X            Impact factor:   6.860


  2 in total

1.  Prostaglandins in pathological bone resorption.

Authors:  W Harvey; S Meghji
Journal:  Agents Actions       Date:  1986-10

2.  Arachidonic acid supplementation does not affect N-methyl-N-nitrosourea-induced renal preneoplastic lesions in young Lewis rats.

Authors:  Katsuhiko Yoshizawa; Yuko Emoto; Yuichi Kinoshita; Ayako Kimura; Norihisa Uehara; Takashi Yuri; Nobuaki Shikata; Tomohito Hamazaki; Airo Tsubura
Journal:  Oncol Lett       Date:  2013-01-30       Impact factor: 2.967

  2 in total

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